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http://dx.doi.org/10.5487/TR.2016.32.2.109

External Application of Apo-9'-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis  

Han, Sang-Chul (Department of Medicine, School of Medicine, Jeju National University)
Kang, Na-Jin (Department of Medicine, School of Medicine, Jeju National University)
Yoon, Weon-Jong (Jeju Biodiversity Research Institute (JBRI))
Kim, Sejin (Department of Medicine, School of Medicine, Jeju National University)
Na, Min-Chull (Department of Medicine, School of Medicine, Jeju National University)
Koh, Young-Sang (Department of Medicine, School of Medicine, Jeju National University)
Hyun, Jin-Won (Department of Medicine, School of Medicine, Jeju National University)
Lee, Nam-Ho (Department of Chemistry, College of Natural Science, Jeju National University)
Ko, Mi-Hee (Jeju Biodiversity Research Institute (JBRI))
Kang, Hee-Kyoung (Department of Medicine, School of Medicine, Jeju National University)
Yoo, Eun-Sook (Department of Medicine, School of Medicine, Jeju National University)
Publication Information
Toxicological Research / v.32, no.2, 2016 , pp. 109-114 More about this Journal
Abstract
Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9'-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9'-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9'-fucoxanthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9'-fucoxanthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9'-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9'-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases.
Keywords
Apo-9'-fucoxanthinone; Atopic dermatitis; 2, 4-Dinitrochlorobenzene; Immunoglobulin E; Phorbol 12-myristate 13-acetate; Ionomycin;
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