Single- and Repeat-dose Oral Toxicity Studies of Lithospermum erythrorhizon Extract in Dogs |
Nam, Chunja
(Biotoxtech Co., Ltd.)
Hwang, Jae-Sik (Biotoxtech Co., Ltd.) Kim, Myoung-Jun (Biotoxtech Co., Ltd.) Choi, Young Whan (Department of Horticultural Bioscience, Pusan National University) Han, Kyoung-Goo (Biotoxtech Co., Ltd.) Kang, Jong-Koo (Biotoxtech Co., Ltd.) |
1 | Chen, X., Yang, L., Oppenheim, J.J. and Howard, M.Z. (2002) Cellular pharmacology studies of shikonin derivatives. Phytother. Res., 16, 199-209. DOI ScienceOn |
2 | Rajasekar, S., Park D.J., Park, C., Park, S., Park, Y.H., Kim, S.T., Choi, Y.H. and Choi, Y.W. (2012) In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma. J. Ethnopharmacol., 144, 335-345. DOI ScienceOn |
3 | Lee, C.C., Wang, C.N., Lai, Y.T., Kang, J.J., Liao, J.W., Chiang, B.L., Chen, H.C. and Cheng, Y.W. (2010) Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma. Br. J. Pharmacol., 161, 1496-1511. DOI ScienceOn |
4 |
Andujar, I., Rios, J.L., Giner, R.M. and Recio, M.C. (2013) Shikonin promotes intestinal wound healing in vitro via induction of TGF- |
5 | Karayannopoulou, M., Tsioli, V., Loukopoulos, P., Anagnostou, T.L., Giannakas, N., Savvas, I., Papazoglou, L.G. and Kaldrymidou, E. (2011) Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog. Can. J. Vet. Res., 75, 42-48. |
6 | Min, R., Tong, J., Wenjun, Y., Wenhu, D., Xiaojian, Z., Jiacai, H., Jian, Z., Wantao, C. and Chenping, Z. (2008) Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway. Phytother. Res., 22, 407-415. DOI ScienceOn |
7 | Yingkun, N., Lysong, Z. and Huimin, Y. (2010) Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells. Can. J. Physiol. Pharmacol., 88, 1138-1146. DOI |
8 | Chang, I.C., Huang, Y.J., Chiang, T.I., Yeh, C.W. and Hsu, L.S. (2010) Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. Biol. Pharm. Bull., 33, 816-824. DOI ScienceOn |
9 | Mao, X., Yu, C.R., Li, W.H. and Li, W.X. (2008) Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells. Cell Res., 18, 879-888. DOI ScienceOn |
10 | Yang, H., Zhou, P., Huang, H., Chen, D., Ma, N., Cui, Q.C., Shen, S., Dong, W., Zhang, X., Lian, W., Wang, X., Dou, Q.P. and Liu, J. (2009) Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo. Int. J. Cancer, 124, 2450-2459. DOI ScienceOn |
11 | Chen, C.H., Lin, M.L., Ong, P.L. and Yang, J.T. (2012) Novel multiple apoptotic mechanism of shikonin in human glioma cells. Ann. Surg. Oncol., 19, 3097-3106. DOI ScienceOn |
12 | Lee, H.J., Lee, H.J., Magesh, V., Nam, D., Lee, E.O., Ahn, K.S., Jung, M.H., Ahn, K.S., Kim, D.K., Kim, J.Y. and Kim, S.H. (2008) Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in lewis lung carcinoma-bearing mice. Yakugaku Zasshi, 128, 1681-1688. DOI ScienceOn |
![]() |