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http://dx.doi.org/10.5487/TR.2014.30.4.297

Peppermint Oil Promotes Hair Growth without Toxic Signs  

Oh, Ji Young (Department of Beauty, Daeduk College)
Park, Min Ah (Department of Public Health, Keimyung University)
Kim, Young Chul (Department of Public Health, Keimyung University)
Publication Information
Toxicological Research / v.30, no.4, 2014 , pp. 297-304 More about this Journal
Abstract
Peppermint (Mentha piperita) is a plant native to Europe and has been widely used as a carminative and gastric stimulant worldwide. This plant also has been used in cosmetic formulations as a fragrance component and skin conditioning agent. This study investigated the effect of peppermint oil on hair growth in C57BL/6 mice. The animals were randomized into 4 groups based on different topical applications: saline (SA), jojoba oil (JO), 3% minoxidil (MXD), and 3% peppermint oil (PEO). The hair growth effects of the 4-week topical applications were evaluated in terms of hair growth, histological analysis, enzymatic activity of alkaline phosphatase (ALP), and gene expression of insulin-like growth factor-1 (IGF-1), known bio-markers for the enhanced hair growth. Of the 4 experimental groups, PEO group showed the most prominent hair growth effects; a significant increase in dermal thickness, follicle number, and follicle depth. ALP activity and IGF-1 expression also significantly increased in PEO group. Body weight gain and food efficiency were not significantly different between groups. These results suggest that PEO induces a rapid anagen stage and could be used for a practical agent for hair growth without change of body weight gain and food efficiency.
Keywords
Alkaline phosphatase; Hair growth; Hair follicle; Insulin-like growth factor-1; Peppermint oil;
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