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http://dx.doi.org/10.5487/TR.2014.30.1.027

A Probiotic Preparation Duolac-Gold Ameliorates Dextran Sulphate Sodium-induced Mouse Colitis by Downregulating the Expression of IL-6  

Yoon, Hyunho (R&D Center, Cellbiotech Co. Ltd.)
Yoon, Yeo-Sang (R&D Center, Cellbiotech Co. Ltd.)
Kim, Min-Soo (R&D Center, Cellbiotech Co. Ltd.)
Chung, Myung-Jun (R&D Center, Cellbiotech Co. Ltd.)
Yum, Do-Young (R&D Center, Cellbiotech Co. Ltd.)
Publication Information
Toxicological Research / v.30, no.1, 2014 , pp. 27-32 More about this Journal
Abstract
Probiotics are live microorganisms that confer a health benefit on the host. Duolac-Gold is a mixture of seven probiotic bacteria containing three species of Bifidobacteria, two species of Lactobacillus, and Streptococcus thermophilus. The aim of this study was to assess the anti-inflammatory effects of Duolac-Gold in an inflammatory bowel disease (IBD) mouse model. IBD was induced by administering 1.5% dextran sulfate sodium (DSS) for 10 days. After induction of DSS-induced colitis, Duolac-Gold was orally administered at three different concentrations. Interestingly, Duolac-Gold treatment accelerated IBD healing, and anti-inflammatory activity was assessed by weight loss, length of the colon, and a microscopic damage score by histology. The expression of inflammatory related cytokines was measured in colon tissues and serum. Of these cytokines, the expression of interleukin-6 decreased remarkably after Duolac-Gold treatment. Taken together, these results suggest that Duolac-Gold treatment is effective in IBD healing by regulating IL-6.
Keywords
Inflammatory bowel disease; Duolac-gold; probiotics; Cytokines; Interleukin-6;
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