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http://dx.doi.org/10.5487/TR.2012.28.4.263

Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs  

Kim, Myoung-Seok (Jeollanamdo Development Institute of Traditional Korean Medicine)
Ham, Seoung-Ho (Jeollanamdo Development Institute of Traditional Korean Medicine)
Kim, Jun-Ho (Jeollanamdo Development Institute of Traditional Korean Medicine)
Shin, Ji-Eun (Jeollanamdo Development Institute of Traditional Korean Medicine)
Oh, Jin (Jeollanamdo Development Institute of Traditional Korean Medicine)
Kim, Tae-Won (Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University)
Yun, Hyo-In (Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University)
Lim, Jong-Hwan (Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University)
Jang, Beom-Su (Advanced Radiation Technology Institute/Korea Atomic Energy Research Institute)
Cho, Jung-Hee (Jeollanamdo Development Institute of Traditional Korean Medicine)
Publication Information
Toxicological Research / v.28, no.4, 2012 , pp. 263-268 More about this Journal
Abstract
The aim of this study was to investigate the acute oral toxicity of fermented Scutellariae Radix (JKTMHGu-100) in rats and dogs. JKTM-HGu-100 was orally administered at a dose of 2,000 mg/kg in Sprague-Dawley rats. An escalating single-dose oral toxicity test in beagle dogs was performed at doses of 500, 1000, and 2000 mg/kg with 4-day intervals. Clinical signs, changes in body weight, mortality, and necropsy findings were examined for 2 weeks following oral administration. No toxicological changes related to the test substance nor mortality was observed after administration of a single oral dose of JKTM-HGu-100 in rats or dogs. Therefore, the approximate lethal dose (LD) for oral administration of JKTMHGu-100 in rats was considered to be over 2,000 mg/kg, and the maximum tolerance doses (MTDs) in rats and dogs were also estimated to be over 2,000 mg/kg. These results indicate that JKTM-HGu-100 shows no toxicity in rodents or non-rodents at doses of 2,000 mg/kg or less.
Keywords
Scutellariae Radix; Single oral toxicity; Rat; Dog;
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