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http://dx.doi.org/10.5487/TR.2012.28.4.249

Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema  

Ahn, Mi Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Han, Jea Woong (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Yoon, Hyung Joo (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Hwang, Jae Sam (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Yun, Eun Young (Department of Agricultural Biology, National Academy of Agricultural Science, RDA)
Publication Information
Toxicological Research / v.28, no.4, 2012 , pp. 249-253 More about this Journal
Abstract
In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.
Keywords
Edema; Bumblebee alcohol extract;
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