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http://dx.doi.org/10.5487/TR.2012.28.1.051

The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application  

Kim, Dong-Ha (Department of Dermatology, Chung-Ang University College of Medicine)
Lim, Yun-Young (Department of Dermatology, Chung-Ang University College of Medicine)
Kim, Hyeong-Mi (Department of Dermatology, Chung-Ang University College of Medicine)
Kim, So-Young (Department of Dermatology, Chung-Ang University College of Medicine)
Kim, Beom-Joon (Department of Dermatology, Chung-Ang University College of Medicine)
Park, Sung-Gil (NOVACELL Technology)
Lee, Tae-Hoon (NOVACELL Technology)
Cho, Soo-Muk (Functional Food & Nutrition Division, National Academy of Agricultural Science, Rural Development Administration)
Publication Information
Toxicological Research / v.28, no.1, 2012 , pp. 51-56 More about this Journal
Abstract
A novel synthetic hexapeptide (SFKLRY-$NH_2$) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-$NH_2$ on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-$NH_2$ in HaCaT cells and B16F10 cells. SFKLRY-$NH_2$ induced no skin irritation at low concentration ($10{\mu}m$), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-$NH_2$ in clinical use.
Keywords
PS-SPCL; Safety; Skin irritation test; SFKLRY-$NH_2$; W3 peptide;
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