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http://dx.doi.org/10.5487/TR.2011.27.3.143

Determination of Optimal Toxic Concentration and Accumulation of Cadmium in Broiler Chicks  

Subhan, Fazli (Department of Biotechnology, University of Malakand (Chackdara))
Khan, Ayaz (Department of Biotechnology, University of Malakand (Chackdara))
Wahid, Fazli (Department of Biotechnology, School of Life Sciences, Kyunpook National University)
Shehzad, Adeeb (Department of Biotechnology, School of Life Sciences, Kyunpook National University)
Jan, Amin Ullah (Department of Breeding and Genetic, Agriculture University of Peshawar)
Publication Information
Toxicological Research / v.27, no.3, 2011 , pp. 143-147 More about this Journal
Abstract
Cadmium is considered one of the most toxic, non biodegradable heavy metal for the human and animals. The purpose of the present study was to investigate the changes in biochemical parameters of blood and accumulation of cadmium in various tissue caused by various levels of dietary cadmium chloride ($CdCl_2$) in broiler chicks. $CdCl_2$ was administered through drinking water to broiler chicks. In spectral analysis, $CdCl_2$ treatment caused a significant increase in Glutamate pyruvate transaminase (GPT), creatinine and uric acid levels in all treated groups. Intriguingly, the GPT, creatinine, and uric acid levels were significantly higher at 75 mg/kg as compared to the groups treated with high doses (100, 125 and 150 mg/kg) of $CdCl_2$. Atomic Absorption Spectrophotometer (AAS) was used for the determination of Cd accumulation in kidney, liver and Breast muscles. AAS analysis revealed that Cd accumulation is increased in breast muscles as compared to liver and kidney at higher doses of Cd than 75 mg/kg.
Keywords
Cadmium; Broiler chicks; Toxicity; Biochemical parameters;
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1 Savage, S.M., Donaldson, L.A., Cherian, S., Chilukuri, R., White, V.A. and Sopori, M.L. (1991). Effects of cigarette smoke on the immune response. II. Chronic exposure to cigarette smoke inhibits surface immunoglobulin-mediated responses in B cells. Toxicol. Appl. Pharmacol., 111, 523-529.   DOI   ScienceOn
2 Thevenod, F. (2003). Nephrotoxicity and the proximal tubule Insights from cadmium. Nephron Physiol., 93, 87-93.   DOI   ScienceOn
3 Uyanik, F., Eren, M., Atasever, A., Tunoku, G. and Kolsuz1, A.H. (2001). Changes in some biochemical parameters and organs of broilers exposed to cadmium and effect of zinc on cadmium induced alterations. Veterinary Medicine, 56.
4 Wang, H., Zhu, G., Shi, Y., Wenig, S., Jin, T., Kong, Q. and Nordberg, G.F. (2003). Influence of environmental cadmium exposure on forearm bone density. J. Bone Miner. Res., 18, 553-560.   DOI   ScienceOn
5 Weisman, R.S., Gold, L.R., Frank, N.E. Flomenbaun, N.A., Lewin, R.S., Weisma, M.A., Howland and Hoffan, R.J. (1998). The pathophysiologic bases of medical toxicity. Toxicol. Emergencies, 6, 135-137.
6 Krisha, M.C. (2008). Cadmium Toxicity (Cadmium Poisoning), Medical Care.
7 Kumar and Clark (2005). Clinical medicine. Elsevier saunders. 6th edition.
8 Lorico, A., Bertola, A., Baum, C., Fodstad, O. and Rapp, G. (2002). Role of the multidrug resistance protein 1 in protection from heavy metal oxyanions: investigations in vitro and in MRP1-deficient mice. Biochem. Biophys. Res. Commun., 291, 617-622.   DOI   ScienceOn
9 Lupo, S., Hewitt, W.R. and Rush, G.F. (1986). Cadmium toxicity in the isolated perfused rat liver. Toxicol. Lett., 34, 5-11.   DOI   ScienceOn
10 Rajannat, B., Hobson, M., Reese, J., Sample, E. and Chapatwala, K.D. (1984). Chronic hepatic and renal toxicity by cadmium in rats. Drug Chem. Toxicol., 7, 229-241.   DOI
11 Remington, (2000). The science and practice of pharmacy, 1, 20th edition, 565.
12 Akyolcu, M.C., Ozcelik, D., Dursun, S., Toplan, S. and Kahraman, R. (2003). Accumulation of cadmium in tissue and its effect on live performance. J. Phys. IV France, 107, 33-36.   DOI
13 Reynders, H., Van Campenhout, K., Bervoets, L., De Coen, W.M. and Blust, R. (2006). Dynamics of cadmium accumulation and effects in common carp (Cyprinus carpio) during simultaneous exposure to water and food (Tubifex tubifex). Environ. Toxicol. Chem., 25, 1558-1567.   DOI   ScienceOn
14 Sant'Ana, M.G., Moraes, R. and Bernardi, M.M. (2005). Toxicity of cadmium in Japanese quail: Evaluation of body weight, hepatic and renal function, and cellular immune response. Environ. Res., 99, 273-277.   DOI   ScienceOn
15 Satarug, S. and Moore, M.R. (2004). Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ. Health Perspect., 112, 1099-1103.   DOI
16 Berzina, N., Markovs, J., Isajevs, S., Apsite, M. and Smirnova, G. (2007). Cadmium-induced enteropathy in domestic cocks: a biochemical and histological study after subchronic exposure. Basic Clin. Pharmacol. Toxicol., 101, 29-34.
17 Dehn, P.F., White, C.M., Conners, D.E., Shipkey, G. and Cumbo, T.A. (2004). In vitro characterization of the human hepatocellular carcinoma (hepg2) cell lines an in vitro model of cadmium toxicity studies. In Vitro Cell Dev. Biol. Anim., 40, 172-182.   DOI   ScienceOn
18 Haouen, S., Hmad, N., Najjar, M.F., El Hani, A. and Sakly, R. (2007). Accumulation of cadmium and its effects on liver and kidney functions in rats given diet containing cadmium-polluted radish bulb. Exp. Toxicol. Pathol., 59, 77-80.   DOI   ScienceOn
19 El-Sharak, A.S., Newair, A.A., Badreldeen, M.M., Ewada, S.M. and Sheweita. S.A. (2007). Protective role of selenium against renal toxicity induced by cadmium in rats. Toxicology, 235, 185-193.   DOI   ScienceOn
20 Ernest, H. and Robret, C.S. (2002). Introduction to Biochemical Toxicology. 3rd Ed. New York, USA, 502-503.
21 Jin, T., Nordber, G.F. and Nordberg, M. (1986). Uptake of cadmium in isolated kidney cells-influence of binding form and in vivo pretreatment. J. Appl. Toxicol., 6, 397-400.   DOI
22 Klaassen, C.D., Casarettand, E.D. and Doull's, T. (2001). The Basic Science of Poisons 6th edition.