Genome-Wide Transcriptional Response During the Development of Bleomycin-Induced Pulmonary Fibrosis in Sprague-Dawley Rats |
Park, Han-Jin
(Division of Research and Development, Korea Institute of Toxicology)
Yang, Mi-Jin (Division of Inhalation Toxicology, KIT Jeongeup Campus) Oh, Jung-Hwa (Division of Research and Development, Korea Institute of Toxicology) Yang, Young-Su (Division of Inhalation Toxicology, KIT Jeongeup Campus) Kwon, Myung-Sang (Division of Research and Development, Korea Institute of Toxicology) Song, Chang-Woo (Division of Inhalation Toxicology, KIT Jeongeup Campus) Yoon, Seok-Joo (Division of Research and Development, Korea Institute of Toxicology) |
1 | Zhu, Z., Homer, R.J., Wang, Z., Chen, Q., Geba, G.P., Wang, J., Zhang, Y. and Elias, J.A. (1999). Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J. Clin. Invest., 103, 779-788. DOI ScienceOn |
2 | Zuo, F., Kaminski, N., Eugui, E., Allard, J., Yakhini, Z., Ben-Dor, A., Lollini, L., Morris, D., Kim, Y., DeLustro, B., Sheppard, D., Pardo, A., Selman, M. and Heller, R.A. (2002). Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc. Natl. Acad. Sci. USA,99, 6292-6297. DOI ScienceOn |
3 | Selman, M., Thannickal, V.J., Pardo, A., Zisman, D.A., Martinez, F.J. and Lynch, J.P., 3rd. (2004). Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. Drugs, 64, 405-430. DOI |
4 | Sime, P.J., Xing, Z., Graham, F.L., Csaky, K.G. and Gauldie, J. (1997). Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest., 100, 768-776. DOI ScienceOn |
5 | Smith, R.E., Strieter, R.M., Zhang, K., Phan, S.H., Standiford, T.J., Lukacs, N.W. and Kunkel, S.L. (1995). A role for C-C chemokines in fibrotic lung disease. J. Leukoc. Biol., 57, 782-787. |
6 | Wynn, T.A., Cheever, A.W., Jankovic, D., Poindexter, R.W., Caspar, P., Lewis, F.A. and Sher, A. (1995). An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature, 376, 594-596. DOI ScienceOn |
7 | Tokuda, A., Itakura, M., Onai, N., Kimura, H., Kuriyama, T. and Matsushima, K. (2000). Pivotal role of CCR1-positive leukocytes in bleomycin-induced lung fibrosis in mice. J. Immunol., 164, 2745-2751. DOI |
8 | van den Brule, S., Misson, P., Buhling, F., Lison, D. and Huaux, F. (2005). Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-beta. Respir. Res., 6, 84. DOI ScienceOn |
9 | Wynn, T.A. (2004). Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat. Rev. Immunol., 4, 583-594. DOI ScienceOn |
10 | Zhang, H.Y., Gharaee-Kermani, M., Zhang, K., Karmiol, S. and Phan, S.H. (1996). Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am. J. Pathol., 148, 527-37. |
11 | Zhang, K., Gharaee-Kermani, M., Jones, M.L., Warren, J.S. and Phan, S.H. (1994). Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J. Immunol., 153, 4733-4741. |
12 | Oh, J.H., Yang, M.J., Yang, Y.S., Park, H.J., Heo, S.H., Lee, E.H., Song, C.W. and Yoon, S. (2009). Microarray-based analysis of the lung recovery process after stainless-steel welding fume exposure in Sprague-Dawley rats. Inhal. Toxicol., 21, 347-373. DOI |
13 | Perbal, B. (2004). CCN proteins: multifunctional signalling regulators. Lancet, 363, 62-64. DOI ScienceOn |
14 | Piguet, P.F., Collart, M.A., Grau, G.E., Sappino, A.P. and Vassalli, P. (1990). Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis. Nature, 344, 245-247. DOI ScienceOn |
15 | Sakanashi, Y., Takeya, M., Yoshimura, T., Feng, L., Morioka, T. and Takahashi, K. (1994). Kinetics of macrophage subpopulations and expression of monocyte chemoattractant protein-1 (MCP-1) in bleomycin-induced lung injury of rats studied by a novel monoclonal antibody against rat MCP-1. J. Leukoc. Biol., 56, 741-750. |
16 | Pottier, N., Chupin, C., Defamie, V., Cardinaud, B., Sutherland, R., Rios, G., Gauthier, F., Wolters, P.J., Berthiaume, Y., Barbry, P. and Mari, B. (2007). Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3? Am. J. Respir. Crit. Care. Med., 176, 1098-1107. DOI ScienceOn |
17 | Prasse, A., Stahl, M., Schulz, G., Kayser, G., Wang, L., Ask, K., Yalcintepe, J., Kirschbaum, A., Bargagli, E., Zissel, G., Kolb, M., Muller-Quernheim, J., Weiss, J.M. and Renkl, A.C. 2009. Essential role of osteopontin in smoking-related interstitial lung diseases. Am. J. Pathol., 174, 1683-1691. DOI ScienceOn |
18 | Roberts, A.B., Russo, A., Felici, A. and Flanders, K.C. (2003). Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta. Ann. N. Y. Acad. Sci., 995, 1-10. DOI ScienceOn |
19 | Sandler, N.G., Mentink-Kane, M.M., Cheever, A.W. and Wynn, T.A. (2003). Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. J. Immunol., 171, 3655-3667. DOI |
20 | Lloyd, C.M., Minto, A.W., Dorf, M.E., Proudfoot, A., Wells, T.N., Salant, D.J. and Gutierrez-Ramos, J.C. (1997). RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J. Exp. Med., 185, 1371-1380. DOI |
21 | Ma, B., Zhu, Z., Homer, R.J., Gerard, C., Strieter, R. and Elias, J.A. (2004). The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J. Immunol., 172, 1872-1881. DOI |
22 | Munger, J.S., Huang, X., Kawakatsu, H., Griffiths, M.J., Dalton, S.L., Wu, J., Pittet, J.F., Kaminski, N., Garat, C., Matthay, M.A., Rifkin, D.B. and Sheppard, D. (1999). The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell, 96, 319-328. DOI ScienceOn |
23 | Matsui, Y., Jia, N., Okamoto, H., Kon, S., Onozuka, H., Akino, M., Liu, L., Morimoto, J., Rittling, S.R., Denhardt, D., Kitabatake, A. and Uede, T. (2004). Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy. Hypertension, 43, 1195-1201. DOI ScienceOn |
24 | Moeller, A., Ask, K., Warburton, D., Gauldie, J. and Kolb, M. (2008). The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int. J. Biochem. Cell Biol., 40, 362-382. DOI ScienceOn |
25 | Moore, B.B., Paine, R., 3rd, Christensen, P.J., Moore, T.A., Sitterding, S., Ngan, R., Wilke, C.A., Kuziel, W.A. and Toews, G.B. (2001). Protection from pulmonary fibrosis in the absence of CCR2 signaling. J. Immunol., 167, 4368-4377. |
26 | Murray, L.A., Argentieri, R.L., Farrell, F.X., Bracht, M., Sheng, H., Whitaker, B., Beck, H., Tsui, P., Cochlin, K., Evanoff, H.L., Hogaboam, C.M. and Das, A.M. (2008). Hyper-responsiveness of IPF/UIP fibroblasts: interplay between TGFbeta1, IL-13 and CCL2. Int. J. Biochem. Cell. Biol., 40, 2174-2182. DOI ScienceOn |
27 | Gorelik, L. and Flavell, R.A. (2002). Transforming growth factorbeta in T-cell biology. Nat. Rev. Immunol., 2, 46-53. DOI ScienceOn |
28 | Hoffmann, K.F., McCarty, T.C., Segal, D.H., Chiaramonte, M., Hesse, M., Davis, E.M., Cheever, A.W., Meltzer, P.S., Morse, H.C., 3rd and Wynn, T.A. (2001). Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions. Faseb. J., 15, 2545-2547. |
29 | Jordana, M., Dolovich, M., Irving, L.B., Tomioka, M., Befus, D., Gauldie, J. and Newhouse, M.T. (1988). Solute movement across the alveolar-capillary membrane after intratracheally administered bleomycin in rats. Am. Rev. Respir. Dis., 138, 96-100. DOI ScienceOn |
30 | Jakubzick, C., Choi, E.S., Carpenter, K.J., Kunkel, S.L., Evanoff, H., Martinez, F.J., Flaherty, K.R., Toews, G.B., Colby, T.V., Travis, W.D., Joshi, B.H., Puri, R.K., and Hogaboam, C.M. (2004). Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Am. J. Pathol., 164, 1989-2001. DOI ScienceOn |
31 | Kaminski, N., Allard, J.D., Pittet, J.F., Zuo, F., Griffiths, M.J., Morris, D., Huang, X., Sheppard, D. and Heller, R.A. (2000). Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation andfibrosis. Proc. Natl. Acad. Sci. USA, 97, 1778-1783. DOI |
32 | Kang, H.R., Cho, S.J., Lee, C.G., Homer, R.J. and Elias, J.A. (2007). Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bidactivated pathway that involves matrix metalloproteinase-12. J. Biol. Chem., 282, 7723-7732. |
33 | Katsuma, S., Nishi, K., Tanigawara, K., Ikawa, H., Shiojima, S., Takagaki, K., Kaminishi, Y., Suzuki, Y., Hirasawa, A., Yano J., Murakami, Y. and Tsujimoto G. (2001). Molecular monitoring of bleomycin-induced pulmonary fibrosis by cDNA microarray-based gene expression profiling. Biochem. Biophys. Res.Commun., 288, 747-751. DOI ScienceOn |
34 | Kuwano, K., Hagimoto, N. and Hara, N. (2001). Molecular mechanisms of pulmonary fibrosis and current treatment. Curr. Mol. Med., 1,551-573. DOI |
35 | Ashcroft, T., Simpson, J.M. and Timbrell, V. (1988). Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J. Clin. Pathol., 41, 467-470. DOI |
36 | Fertin, C., Nicolas, J.F., Gillery, P., Kalis, B., Banchereau, J. and Maquart, F.X. (1991). Interleukin-4 stimulates collagen synthesis by normal and scleroderma fibroblasts in dermal equivalents. Cell. Mol. Biol., 37, 823-829. |
37 | Belperio, J.A., Keane, M.P., Burdick, M.D., Lynch, J.P., 3rd, Xue, Y.Y., Berlin, A., Ross, D.J., Kunkel, S.L., Charo, I.F. and Strieter, R.M. (2001). Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J. Clin. Invest., 108, 547-556. DOI |
38 | Cortijo, J., Cerda-Nicolas, M., Serrano, A., Bioque, G., Estrela, J.M., Santangelo, F., Esteras, A., Llombart-Bosch, A. and Morcillo, E.J. (2001). Attenuation by oral N-acetylcysteine of bleomycin-induced lung injury in rats. Eur. Respir. J., 17, 1228-1235. DOI ScienceOn |
39 | Doucet, C., Brouty-Boye, D., Pottin-Clemenceau, C., Canonica, G.W., Jasmin, C. and Azzarone, B. (1998). Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma. J. Clin. Invest., 101, 2129-2139. DOI ScienceOn |
40 | Fichtner-Feigl, S., Strober, W., Kawakami, K., Puri, R.K. and Kitani, A. (2006). IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat. Med., 12, 99-106. DOI ScienceOn |
41 | Gharaee-Kermani, M., Hu, B., Phan, S.H. and Gyetko, M.R. (2008). The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy. Expert. Opin. Investig. Drugs, 17, 905-916. DOI ScienceOn |
42 | Gharaee-Kermani, M. and Phan, S.H. (2005). Molecular mechanisms of and possible treatment strategies for idiopathic pulmonary fibrosis. Curr. Pharm. Des., 11, 3943-3971. DOI |
43 | Gharaee-Kermani, M., Ullenbruch, M. and Phan, S.H. (2005). Animal models of pulmonary fibrosis. Methods Mol. Med., 117, 251-259. |