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http://dx.doi.org/10.5487/TR.2010.26.2.117

Antifungal Effect of Brachyglottis repanda Ethanol Extract  

Yook, Chan-Nam (Department of Food Science, Wonkwang Health Science)
Na, Young-Soon (Division of Bionanochemistry, College of Natural Sciences, Wonkwang University)
Choi, Hwa-Jung (Department of Clinical Pathology, Daejeon Health Science College)
You, Il-Soo (Department of Nanopolymer, National Chonbuk University)
Baek, Jong-Min (R&D Center, BRNScience Co. LTD., Seoul National University)
Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Toxicological Research / v.26, no.2, 2010 , pp. 117-121 More about this Journal
Abstract
The crude ethanol extract of B. repanda showed the cytotoxic activity against Polio virus (25% activity at $150{\mu}g$/disk) and the minor cytotoxic activity against BSC cells (African green monkey kidney). However, the crude ethanol extract of B. repanda was non-toxic to murine leukaemia cells CCL 46 P388D1 ($IC_{50}$, > 62,500 ng/ml). Cytotoxic and antifungal activities were strongly shown by Fr. 64-3 which was eluted with 90% $CH_3CN/H_2O$, 100% $CH_3CN$, and 50% $CH_3CN/H_2O$(SM 2 at $150{\mu}g$/disk). The fraction 64-3 also showed the most cytotoxic activity against murine leukaemia cells (128 mg, $IC_{50}$ 10,051 ng/ml at $75{\mu}g$/disk). These results suggest that this fraction has a potent antifungal activity against the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185.
Keywords
Brachyglottis repanda; Cytotoxic activity; Murine leukaemia cell lines; Trichophyton mentagrophytes; Antifungal activity; Antiviral activity;
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