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http://dx.doi.org/10.5487/TR.2008.24.3.183

Strain-dependent Differences of Locomotor Activity and Hippocampus-dependent Learning and Memory in Mice  

Kim, Joong-Sun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University)
Yang, Mi-Young (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University)
Son, Yeong-Hoon (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University)
Kim, Sung-Ho (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University)
Kim, Jong-Choon (Department of Veterinary Toxicology, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University)
Kim, Seung-Joon (Department of Veterinary Obstetrics, College of Veterinary Medicine, Kyungpook National University)
Lee, Yong-Duk (Department of Veterinary Anatomy, College of Veterinary Medicine, Cheju National University)
Shin, Tae-Kyun (Department of Veterinary Anatomy, College of Veterinary Medicine, Cheju National University)
Moon, Chang-Jong (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Center, Chonnam National University)
Publication Information
Toxicological Research / v.24, no.3, 2008 , pp. 183-188 More about this Journal
Abstract
The behavioral phenotypes of out-bred ICR mice were compared with those of in-bred C57BL/6 and BALB/c mice. In particular, this study examined the locomotor activity and two forms of hippocampus-dependent learning paradigms, passive avoidance and object recognition memory. The basal open-field activity of the ICR strain was greater than that of the C57BL/6 and BALB/c strains. In the passive avoidance task, all the mice showed a significant increase in the cross-over latency when tested 24 hours after training. The strength of memory retention in the ICR mice was relatively weak and measurable, as indicated by the shorter cross-over latency than the C57BL/6 and BALB/c mice. In the object recognition memory test, all strains had a significant preference for the novel object during testing. The index for the preference of a novel object was lower for the ICR and BALB/c mice. Nevertheless, the variance and the standard deviation in these strains were comparable. Overall, these results confirm the strain differences on locomotor activity and hippocampus-dependent learning and memory in mice.
Keywords
Behavioral difference; Mouse strain; Locomotor activity; Passive avoidance; Object recognition memory;
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