Intravenous Single and Two Week Repeated Dose Toxicity Studies of Rice Cells-derived Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor on Rats |
Ji, Jung-Eun
(Department of Environmental & Health Chemistry)
Lee, Jung-Min (Department of Environmental & Health Chemistry) Choi, Jong-Min (Department of Environmental & Health Chemistry) Choi, Young-Hwa (Department of Environmental & Health Chemistry) Kim, Seok-Kyun (Department of Environmental & Health Chemistry) Ahn, Kyong-Hoon (Department of Environmental & Health Chemistry) Lee, Dong-Hoon (Department of Environmental & Health Chemistry) Kim, Ha-Hyung (Physical Pharmacy Laboratory, College of Pharmacy, Chung-Ang University) Han, Kyu-Boem (Hanson Biotech Co., Ltd.) Kim, Dae-Kyong (Department of Environmental & Health Chemistry) |
1 | Daniell, H., Streat, S.J. and Wycoff, K. (2001). Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants. Trends Plant Sci., 6, 219-226 DOI ScienceOn |
2 | Doran, P. (2000). Foreign protein production in plant tissue cultures. Curr. Opin. Biotechnol., 11, 199-204 |
3 | Hovgaard, D., Mortensen, B.T., Schifter, S. and Nissen, N.I. (1993). Comparative pharmacokinetics of single-dose administration of mammalian and bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor. Eur. J. Haematol., 50, 32-36 |
4 | Rasko, J.E. and Gough, N.M. (1994). Granulocyte-macrophage colony stimulating factor. In: Thomson, A. (Ed.), The cytokine handbook. Academic Press, London, pp. 343- 369 |
5 | Wadhwa, M., Skog, A.-L., Bird, C., Ragnhammar, P., Liljefors, M., Gaines-Das, R., Mellstedt, H. and Thorpe, R. (1999). Immunogenicity of granulocyte-macrophage colony- stimulating factor (GM-CSF) products in patients undergoing combination therapy with GM-CSF. Clin. Cancer Res., 5, 1353-1361 |
6 | Armitage, J.O. (1998). Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. Blood, 92, 4491-4508 |
7 | Shin, Y.J., Hong, S.Y., Kwon, T.H., Jang, Y.S. and Yang, M.S. (2003). High level of expression of recombinant human granulocyte-macrophage colony stimulating factor in transgenic rice cell suspension culture. Biotechnol. Bioeng., 82, 778-783 DOI ScienceOn |
8 | Ganz, P., Dudani, A., Tackaberry, E., Sardana, R.K., Sauder, C. and Altosaar, I. (1996). In: Owen, M.R.L. and Pen, J. (Eds.). Expression of human blood proteins in transgenic plants: the cytokine GM-CSF as a model protein. Wiley, London, UK, pp. 281-297 |
9 | Song, S.W., Jung, W. and Hong, D.H. (2006). Thirteen-week repeated-dose toxicity studies of STB-HO-BM in rats. J. Toxicol. Pub. Health, 22, 135-144 과학기술학회마을 |
10 | Kwon, T.H., Kim, Y.S., Lee, J.H. and Yang, M.S. (2003). Production and secretion of biologically active human granulocyte- macrophage colony stimulating factor in transgenic tomato suspension cultures. Biotechnol. Lett., 25, 1571- 1574 DOI ScienceOn |
11 | Ragnhammar, P., Friesen, H.J., Frodin, J.-E., Lefvert, A.K., Hassan, M., Osterborg, A. and Mellstedt, H. (1994). Induction of anti-recombinant human granulocyte-macrophage colony-stimulating factor (Escherichia coliderived) antibodies and clinical effects in nonimmunocompromised patients. Blood, 84, 4078-4087 |
12 | Lorke, D. (1983). A new approach to practical acute toxicity testing. Arch. Toxicol., 54, 275-287 DOI |
13 | Kim, Y.C., Kim, H.J., Kong, M.K., Lim, A.K., Kwon, M.H., Kim, K.S. and Lee, G.D. (2007). Single and four-week repeated oral toxicity study of antidiabetic herb extract microcapsule in sprague-dawley rats. J. Toxicol. Pub. Health., 23, 87-96 과학기술학회마을 DOI ScienceOn |
14 | Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275 |
15 | Cho, S.A., Park, J.H., Seok, S.H., Juhn, J.H., Kim, S.J., Ji, H.J., Choo, Y.S. and Park, J.H. (2006). Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches. Exper. Toxicol. Pathol., 57, 321-328 DOI ScienceOn |
16 | Van den Steen, P., Rudd, P.M., Dwek, R.A., Van Damme, J. and Opdenakker, G. (1998). Cytokine and protease glycosylation as a regulatory mechanism in inflammation and autoimmunity. Adv. Exp. Med. Biol., 435, 133-143 DOI |
17 | Han, J.H., Chung, H., Lee, J.H., Suh, J.E., Lee, G.S., Kim, J.C. and Kang, B.H. (2004). Single and two-week repeated oral dose toxicity study of DHP2, a hydrophobic drug delivery vehicle in mice. J. Toxicol. Pub. Health., 20, 123-129 |
18 | Morrissey, P.J., Bressler, L., Park, L.S., Alpert, A. and Gillis, S. (1987). Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells. J. Immunol., 139, 1113-1119 |
19 | Lieschke, G.J. and Burgess, A.W. (1992). Granulocyte colonystimulating factor and granulocyte-macrophage colonystimulating factor. N. Engl. J. Med., 327, 99-106 DOI ScienceOn |