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Effects of Propyl Pyrazole Triol on the Blood Vessel-Dilation and Cellular Morphology of Liver and Kidney in Adult Male Mouse  

Lee, Eun-Jung (Department of Biology, College of Natural Sciences, Sunchon National University)
Lee, Yu-Mi (Department of Biology, College of Natural Sciences, Sunchon National University)
Choe, Eun-Sang (Department of Biology, College of Natural Sciences, Pusan National University)
Seong, Chi-Nam (Department of Biology, College of Natural Sciences, Sunchon National University)
Cho, Hyun-Wook (Department of Biology, College of Natural Sciences, Sunchon National University)
Publication Information
Toxicological Research / v.22, no.4, 2006 , pp. 365-373 More about this Journal
Abstract
The present study was designed to characterize the effects of estrogen receptor agonist (4,4',4'-(4-Propyl-[1H]-pyrazole-1,3,5-triyl) trisphenol, PPT) on liver and kidney in male mouse using a light microscopic analysis. PPT was subcutaneously given to adult male mice at a weekly dosage of 178.6mg/kg in a volume 0.08 ml of vehicle for 3, 5 and 8 weeks. There were differences in body and organ weights between control and the treated groups. Body and kidney weights were decreased in treated group whereas, liver weight was increased. In microscopic observations, sinusoidal diameter in liver of treated group was increased 156%, 216% and 255% on week 3, 5 and 8 respectively. Compared to the control, diameter of proximal convoluted tubules in kidney was increased 37% and 43% or week 5 and 8 in treated group. Whereas, height of epithelial cells in the proximal tubules was reduced at all time points. These results suggest that microstructure of liver and kidney was changed by treatment of estrogen receptor agonist PPT in the male mice.
Keywords
Estrogen receptor; Propyl pyrazole triol; Liver; Kidney; Male mouse;
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