Magnolol Inhibits iNOS, p38 Kinase, and NF-κB/Rel in Murine Macrophages |
Li Mei Hong
(Department of Pharmacology, Chosun University College of Medicine)
Chang In-Youp (Department of Anatomy, Chosun University College of Medicine) Youn Ho-Jin (Department of Pharmacology, Chosun University College of Medicine) Jang Dae-Sik (Korea Institute of Oriental Medicine) Kim Jin-Sook (Korea Institute of Oriental Medicine) Jeon Young-Jin (Department of Pharmacology, Chosun University College of Medicine) |
1 | Chen, Y.H., Lin, S.J., Chen, J.W., Ku, H.H. and Chen, Y.L. (2002): Magnolol attenuates VCAM-1 expression in vitro in TNF-a-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits. Br. J. Pharmacol., 135, 37-47 DOI ScienceOn |
2 | Chomczynski, P. and Mackey, K. (1995): Substitution of chloroform by bromo-chloropropane in the single-step method of RNA isolation. Anal. Biochem., 225, 163-164 DOI ScienceOn |
3 | Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., et al. (1995): SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS. Lett., 364, 229-233 DOI ScienceOn |
4 | Da Silva, J., Pierrat, B., Mary, J.L. and Lesslauer, W. (1997): Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J. Biol. Chem., 272, 28373-28380 DOI ScienceOn |
5 | Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S. and Tannenbaum, S.R. (1982): Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem., 126, 131-138 DOI ScienceOn |
6 | Rietschel, E.T. and Brade, H. (1992): Bacterial endotoxins. Sci. Am., 267, 54-61 DOI ScienceOn |
7 | Wang, J.P., Hsu, M.F., Raung, S.L., Chang, L.C., Tsao, L.T., Lin, P.L., et al. (1999): Inhibition by magnolol of formylmethionyl- leucyl-phenylalanine-induced respiratory burst in rat neutrophils. J. Pharm. Pharmacol., 51, 285-294 DOI |
8 | Wang, J.P., Hsu, M.F., Raung, S.L., Chen, C.C., Kuo, J.S. and Teng, C.M. (1992): Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch. Pharmacol., 346, 707-712 |
9 | Wang, J.P., Lin, P.L., Hsu, M.F. and Chen, C.C. (1998): Possible involvement of protein kinase C inhibition in the reduction of phorbol ester-induced neutrophil aggregation by magnolol in the rat. J. Pharm. Pharmacol., 50, 1167-1172 DOI |
10 | Xie, Q.W., Qhisnant, R. and Nathan, C. (1993): Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-g and bacterial lipopolysaccharide. J. Exp. Med., 177, 1779-1784 DOI ScienceOn |
11 | Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J., et al. (1995): Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem., 270, 7420-7426 DOI ScienceOn |
12 |
Foey, A.D., Parry, S., Williams, L.M., Feldmann, M., Foxwel,l B.M. and Brennan, F.M. (1998): Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF- |
13 | Jeon, Y.J., Kim, Y.G., Lee, M., Park, S.M., Han, S.B. and Kim, H.M. (2000): Radicicol suppresses expression of inducible nitric oxide synthase by blocking p38 kinase and nuclear factor-kB/Rel in lipopolysaccharide-stimulated macrophages. J. Pharmacol. Exp. Ther., 294, 548-554 |
14 | Lee, J.C. and Young, P.R. (1996): Role of CSB/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J. Leukoc. Biol., 59, 152-157 DOI |
15 | Dunnett, M. (1955) A multiple comparison procedure for comparing several treatments with a control. J. Am. Statistics Assoc., 50, 1096-1121 DOI |
16 | Jeon, Y.J., Han, S.H., Lee, Y.W., Yea, S.S. and Yang, K.H. (1998): Inhibition of NF-kappa B/Rel nuclear translocation by dexamethasone: mechanism for the inhibition of iNOS gene expression. Biochem. Mol. Biol. Int., 45, 435-441 |
17 | Xie, Q.W., Kashiwabara, Y. and Nathan, C. (1994): Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem., 269, 4705-4708 |
18 | Hibbs, J.B. Jr., Taintor, R.R. and Vavrin, Z. (1987): Macrophage cytotoxicity: role for Larginine deiminase and imino nitrogen oxidation to nitrite. Science, 235, 473-476 DOI |
19 | Chen, C.C. and Wang, J.K. (1999): p38 but not p44/42 mitogen- activated protein kinase is required for nitric oxide snthase induction mediated by lipopolysaccharide in RAW 264.7 cells. Mol. Pharmacol., 55, 481-488 |
20 |
Teng, C.M., Yu, S.M., Chen, C.C., Huang, Y.L. and Huang, T.F. (1990): EDRF-release and |
21 | Beyaert, R., Cuenda, A., Vanden Berghe, W., Plaisance, S., Lee, J.C., Haegeman, G., et al. (1996): The p38/RK mitogen- activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J., 15, 1914-1923 |
22 | Palmer, R.M., Ashton, D.S. and Moncada, S. (1988): Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature, 333, 664-666 DOI ScienceOn |
23 | Lee, J., Jung, E., Park, J., Jung, K., Lee, S., Hong, S., Park, J., Park, E., Kim, J., Park, S. and Park, D. (2005): Antiinflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling. Planta. Med., 71, 338-343 DOI ScienceOn |
24 | Lowenstein, C.J., Alley, E.W., Raval, P., Snowman, A.M., Snyder, S.H., Russell, S.W., et al. (1993): Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc. Natl. Acad. Sci. U.S.A., 90, 9730-9734 |
25 | Dudley, D.T., Pang, L., Decker, S.J., Bridges, A.J. and Saltiel, A.R. (1995): A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U.S.A., 92, 7686-7689 |
26 | Matsuda, H., Kageura, T., Oda, M., Morikawa, T., Sakamoto, Y. and Yoshikawa, M. (2001): Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages. Chem. Pharm. Bull, 49, 716-720 DOI ScienceOn |
27 | Fujita, S. and Taira, J. (1994): Biphenyl compounds are hydroxy radical scavengers: their effective inhibition for UV-induced mutation in Salmolella typhimurium TA102. Free Radic. Biol. Med., 17, 273-277 DOI ScienceOn |
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