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Tungtungmadic Acid Isolated from Salicornia herbacea Suppresses the Progress of Carbon Tetrachloride-induced Hepatic Fibrosis in Mice  

Chung, Young-Chul (Division of Food Science, Chinju International University)
Choi, Jae-Ho (Department of Pharmacy, College of Pharmacy and Research Center for Proteineous Materials, Chosun University)
Oh, Kyo-Nyeo (Department of Pharmacy, College of Pharmacy and Research Center for Proteineous Materials, Chosun University)
Chun, Hyo-Kon (Korea Research Institute of Bioscience and Biotechnology)
Jeong, Hye-Gwang (Department of Pharmacy, College of Pharmacy and Research Center for Proteineous Materials, Chosun University)
Publication Information
Toxicological Research / v.22, no.3, 2006 , pp. 267-273 More about this Journal
Abstract
Tungtungmadic acid(3-caffeoyl, 4-dihydrocaffeoyl quinic acid: CDCQ) is a new chlorogenic acid derivative isolated from the Salicornia herbacea. The suppressive effects of CDCQ on the progress of acute carbon tetrachloride($CCl_4$)-induced hepatic fibrosis were investigated in mice. CDCQ significantly suppressed $CCl_4$-induced hepatic necrosis and inflammation, as determined by serum enzymatic activities of alanine and aspartate aminotransferase and serum TNF-$\alpha$ levels in a dose-dependent manner. In addition, increased hepatic lipid peroxidation and fibrosis after acute $CCl_4$ treatment were suppressed by the administration of CDCQ. CDCQ also significantly prevented the elevation of hepatic hydroxyproline and collagen content and ${\alpha}$-smooth muscle actin(${\alpha}$-SMA) expression in the liver of $CCl_4$-intoxicated mice. These results suggest that the suppressive effects of CDCQ against the acute $CCl_4$-induced hepatic fibrosis possibly related to its ability to block both hepatic inflammation and the activation of hepatic stellate cells.
Keywords
Tungtungmadic acid; Carbon tetrachloride; Hepatic fibrosis; Collagen; Inflammation;
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Times Cited By KSCI : 2  (Citation Analysis)
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