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Association Study between the Genetic Variants of the Human Atrial Natriuretic Peptide Gene and Essential Hypertension in Korean Population  

Bae Joon-Seol (Department of Biochemistry, College of Science, Yonsei University)
Kang Byung-Yong (Research Institute for Life Science, Sahmyook University)
Lee Kang-Oh (Research Institute for Life Science, Sahmyook University)
Lee Seung-Taek (Department of Biochemistry, College of Science, Yonsei University)
Publication Information
Toxicological Research / v.22, no.2, 2006 , pp. 69-74 More about this Journal
Abstract
Hypertension leads to major health problems in many industrialized countries, and multiple etiologic factors are involved in the pathogenesis of this disorder. The genetic components of the natriuretic peptide system might be involved in the pathogenesis of hypertension. In this regard, the atrial natriuretic peptide (ANP) gene has been proposed as a candidate hypertension gene. Therefore, we investigated the G1837A and C-664G polymorphisms of the ANP gene in 143 Korean normotensives and 118 hypertensives. There were no significant differences in the genotype and allele frequencies between the two groups. Although the frequencies in each of these polymorph isms were not significantly different between normotensives and hypertensives, our results provide additional ethnic information for linkage analysis and associated studies of this disorder with cardiovascular disease.
Keywords
ANP; Essential Hypertension; Korean Population;
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1 Kato, N., Sugiyama, T., Morita, H., Nabika, T., Kurihara, H., Yamori, Y. and Yazaki, Y. (2000): Genetic analysis of the atrial natriuretic peptide gene in essential hypertension. Clinical Science, 98, 251-258   DOI   ScienceOn
2 Lewontin, R.C (1964): The interaction of selection and linkage. I. General considerations: heterotic models. Genetics, 49, 49-67
3 Schorr, U., Beige, J., Ringel, J., Turan, S., Kreutz, R., Distler, A. and Sharma, A.M. (1997): HpaII polymorphism of the atrial natriuretic peptide gene and the blood pressure response to salt intake in normotensive men. J. Hypertens, 15, 715-718   DOI
4 Rutledge, D.R., Sun, Y. and Ross, E.A. (1995): Polymorphisms within the atrial natriuretic peptide gene in essential hypertension. J. Hypertens., 13, 953-955   DOI
5 Yang-Feng, T.L., Floyd-Smith, G., Nemur, M., Drouin, J. and Francke, U. (1985): The pronatriodilatin gene is located on the distal short arm of human chromosome 1 and on mouse chromosome 4. Am. J. Hum. Gnenet., 37, 1117- 1128
6 Hill, W.G. and Robertson, A. (1968): Linkage disequilibrium of finite populations. Theor. Appl. Genet., 38, 226-231   DOI   ScienceOn
7 Rahmutula, D., Nakayama, T., Soma, M., Takahashi, Y., Kunimoto, M., Uwabo, J., Sato, M., Izumi, Y., Kanmatsuse, K. and Ozawa, Y. (2001): Association study between the variants of the human ANP gene and essential hypertension. Hypertens. Res., 24, 291-294   DOI
8 Beige, J., Zilch, O., Hohenbleicher, H., Ringel, J., Kunz, R., Distler, A. and Shrma, A.M. (1997): Genetic variants of the renin-angiotensin system and ambulatory blood pressure in essential hypertension. J. Hypertens., 15, 503- 508   DOI
9 Ramasawmy, R., Kotea, N., Lu, C., Sayada, C., Baligadoo, S. and Krishnamoorthy, R. (1993): A new polymorphic restriction site at the atrial natriuretic peptide (hPND) gene locus. Hum. Genet., 91, 509-510
10 Bostein, D., White, R.L., Skolnick, M. and Davis, R.W. (1980): Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet., 32, 314-331
11 Imura, H., Matsuo, H. and Masaki, T. (1990): Peptide regulation of cardiovascular function. In Proceedings of the sixth Takeda Science Foundation symposium on: Harcourt Brace Jovanovich, Japan Inc., Tokyo, pp 3-11
12 Morgan, R., Bishop, A., Owens, D.R., Luzio, S.D., Peters, J.R. and Rees, A. (1990): Allelic variants at insulin-receptor and insulin gene loci and susceptibility to NIDDM in Welsh population. Diabetes,39,1479-1484   DOI   ScienceOn
13 Cheung, B.M.Y., Leung, R., Shiu, S., Tan, K.C.B., Lau, C.-P. and Kumana, C.R. (1999): HpaII polymorphism in the atrial natriuretic peptide gene and hypertension. Am. J. Hypertens., 12, 524-527   DOI   ScienceOn
14 Friedwald, W.T., Levy, R.I. and Fridrickson, D.S. (1972): Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin. Chem., 18, 499-502
15 Rubattu, S., Stanzione, R., Di Angelantonio, E., Zanda, B., Evangelista, A., Tarasi, D., Gigante, B., Pirisi, A., Brunnetti, E. and Volpe, M. (2004): Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans. Stroke, 35, 814-818   DOI   ScienceOn
16 Argentin, S., Nemer, M., Drouin, J., Syvaine, M., Pahlman, R., Tahvanainen, E. and Januianen, M. (1985): The gene for rat atrial natriuretic factor. J. Biol. Chem., 260, 4568- 4571
17 Hollister, A.S. and Inagami, T. (1991): Atrial natriuretic factor and hypertension: a review and meta-analysis. Am. J. Hypertens, 4, 850-865
18 Kangawa, K., Fukuda, A. and Matsuo, H. (1985): Structural identification of $\beta$- and $\gamma$-human atrial natriuretic polypeptide. Nature, 313, 397-400   DOI   ScienceOn