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Single Dose Toxicity Studies of STB-HO-BM in Rats and Dogs  

Song Si-Whan (Preclinical Research Center, ChemOn Inc.)
Jung Winston (SeoBong Biobestech Co.)
Hong Dong-Ho (Green Cross Coporation)
Publication Information
Toxicological Research / v.22, no.2, 2006 , pp. 153-156 More about this Journal
Abstract
The acute toxicity of STB-HO-BM was evaluated in Sprague Dawley (SS) rats and beagle dogs. STB-HO-BM was administered orally to rats at dose levels of 0 and 2,000mg/kg/day and to dogs at dose levels of 0, 500, 1,000 and 2,000 mg/kg/day. In these experiments, there were no death and clinical changes which were related to STB-HO-BM administration. In addition, there were no significant changes between control and treated groups in body weights and autopsy findings. In conclusion, the administration of STB-HO-BM 2,000 mg/kg in SD rats and up to 2,000mg/kg in beagle dogs was proved to be safe, and it is thought that STB-HO-BM may not show any toxicity in its clinical use.
Keywords
STB-HO-BM; Single dose toxicity; Dog; Rat;
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