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Genotoxicity Studies of STB-HO-BM, a Germanium Complex  

Song Si-Whan (Preclinical Research Center, ChemOn Inc.)
Jung Winston (SeoBong Biobestech Co.)
Hong Dong-Ho (Green Cross Coporation)
Publication Information
Toxicological Research / v.22, no.2, 2006 , pp. 145-151 More about this Journal
Abstract
We have investigated the genotoxicity of STB-HO-BM using in vitro and in vivo system such as Ames reverse mutation test, chromosomal aberration test and micronucleus test. in Ames reverse mutation test, STB-HO-BM treatment at the dose range up to 5,000 ug/plate did not induce mutagenicity in Salmonella typhimurium TA98, TA100, TA102, TA1535, TA 1537 and in Escherichia coli WP2 uvrA with and without metabolic activation. Any significant aberration wasn't observed in chinese hamster lung (CHL) fibroblast cells treated with STB-HO-BM at the concentration of 12.5, 2.5, 5 mg/ml both in the absense and presence of metabolic activation system. In mouse micrnucleus test, no significant increase in the occurrence of micronucleated polychromatic erythrocytes was observed in ICR male mice orally administered with STB-HO-BM at the doses of 0.5, 1.0, 2.0 g/kg. These results indicate that STB-HO-BM has no mutagenic potential under the condition in this study.
Keywords
STB-HO-BM; Genotoxicity; Reverse mutation; Chromosome aberration; Micronucleus;
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