Single Oral Dose Toxicity Studies of Polycan, β-Glucan Originated from Aureobasidium in Mice |
Lee, Hyeung-Sik
(Department of Herbal Biotechnology, Daegu Haany University)
Yang, Kun-Ju (Glucan Corp. Research Institute, Marine Biotechnology Center) Shin, Hyun-Dong (Glucan Corp. Research Institute, Marine Biotechnology Center) Park, Bok-Ryeon (Glucan Corp. Research Institute, Marine Biotechnology Center) Son, Chang-Woo (Glucan Corp. Research Institute, Marine Biotechnology Center) Jang, Hee-Jeong (Glucan Corp. Research Institute, Marine Biotechnology Center) Park, Dong-Chan (ENZ BIO Co., Kyungpook National University) Jung, Young-Mi (ENZ BIO Co., Kyungpook National University) Ku, Sae-Kwang (Pharmacology & Toxicology Lab., Central Research Laboratories, Dong Wha Pharm. Ind. Co.) |
1 | Douwes, J. (2005): (1-->3)-Beta-D-glucans and respiratory health: a review of the scientific evidence. Indoor Air, 15, 160-169 DOI PUBMED ScienceOn |
2 | Gu, Y.H., Takagi, Y., Nakamura, T., Hasegawa, T., Suzuki, I., Oshima, M., Tawaraya, H. and Niwano, Y (2005): Enhancement of radioprotection and anti-tumor immunity by yeast-derived beta-glucan in mice. J. Med. Food, 8, 154-158 DOI ScienceOn |
3 | Plat, J. and Mensink, R.P. (2005): Food components and immune function. Curr. Opin. Lipidol., 16, 31-37 DOI PUBMED ScienceOn |
4 | Delaney, B., Carlson, T., Zheng, G.H., Hess, R., Knutson, N., Frazer, S., Ostergren, K., van Zijverden, M., Knippels, L., Jonker, D. and Penninks, A. (2003): Repeated dose oral toxicological evaluation of concentrated barley beta-glucan in CD-1 mice including a recovery phase. Food Chem. Toxicol., 41, 1089-1102 DOI ScienceOn |
5 | Spicer, E.J., Goldenthal, E.I. and Ikeda, T. (1999): A toxicological assessment of curdlan. Food Chem. Toxicol., 37, 455-479 DOI ScienceOn |
6 | US Environmental Protection Agency (1998): Health Effects Test Guidelines OPPTS 870.100, Acute Toxicity Testing Background. US EPA August, Washington, USA |
7 | Braaten, J.T., Scott, F.W., Wood, P.J., Riedel, K.D., Wolynetz, M.S., Brule, D. and Collins, M.W. (1994): High beta-glucan oat bran and oat gum reduce postprandial blood glucose and insulin in subjects with and without type 2 diabetes. Diabet. Med., 11, 312-318 DOI ScienceOn |
8 | Feletti, F., De Bernardi di Valserra, M., Contos, S., Matta-boni, P. and Germogli, R. (1992): Chronic toxicity study on a new glucan extracted from Candida albicans in rats. Arzneimittelforschung, 42, 1363-1367 |
9 | Lia, A., Hallmans, G., Sandberg, A.S., Sundberg, B., Aman, P. and Andersson, H. (1995): Oat beta-glucan increases bile acid excretion and a fiber-rich barley fraction increases cholesterol excretion in ileostomy subjects. Am. J. Clin. Nutr, 62, 1245-1251 DOI |
10 | Korea Food and Drug Administration (1999): Testing Guidelines for Safety Evaluation of Drugs (Notification No. 1999-61, issued by the Korea Food and Drug Administration on December 22, 1999) |
11 | Estrada, A., Yun, C.H., Van Kessel, A., Li, B., Hauta, S. and Laarveld, B. (1997): Immunomodulatory activities of oat beta-glucan in vitro and in vivo. Microbiol. Immunol., 41, 991-998 DOI |
12 | Yan, J., Allendorf, D.J. and Brandley, S. (2005): Yeast whole glucan particle (WGP) beta-glucan in conjunction with antitumour monoclonal antibodies to treat cancer. Expert Opin. Biol. Ther, 5, 691-702 DOI ScienceOn |
13 | Hodge, H.C. and Sterner, J.H. (1949): Tabulation of toxicity classes. Am. Ind. Hyg. Q., 10, 93 |
14 | Seo, H.P., Kim, J.M., Shin, H.D., Kim, T.K., Chang, H.J., Park, S.R. and Lee J. W. (2002): Production of -1,3/1,6glucan by Aureobasidium pullulans SM-2001. Korean J. Bitechnol. Bioeng., 17, 376-380 과학기술학회마을 |
15 | Chihara, G. (1983): Preclinical evaluation of lentinan in animal models. Adv. Exp. Med. Biol., 166, 189-197 |
16 | Duarte, C.G., dos Santos, G.L., Azzolini, A.E. and de Assis Pandochi, A.I. (2000): The effect of the antithyroid drug propylthiouracil on the alternative pathway of complement in rats. Int. J. Immunopharmacol., 22, 25-33 DOI ScienceOn |
17 | Bais, D., Trevisan, A, Lapasin, R, Partal, P and Gallegos, C. (2005): Rheological characterization of polysaccharidesurfactant matrices for cosmetic OIW emulsions. J. Colloid Interface Sci., 290, 546-556 DOI ScienceOn |
18 | Pinzone Fox, M.L., Sastry, M.K., Parenti, D.M. and Simon, G.L. (2005): Plasma leptin concentration increases early during highly active antiretroviral therapy for acquired immunodeficiency syndrome, independent of body weight. J. Endocrinol. Invest., 28, 1-3 DOI |
19 | Bourdon, I., Yokoyama, W., Davis, P., Hudson, C., Backus, R., Richter, D., Knuckles, B. and Schneeman, B.O. (1999): Postprandial lipid, glucose, insulin, and cholecystokinin responses in men fed barley pasta enriched with beta-glucan. Am. J. Clin. Nutr., 69, 55-63 DOI |
20 | Czop, J.K. (1986): The role of beta-glucan receptors on blood and tissue leukocytes in phagocytosis and metabolic activation. Pathol. Immunopathol. Res., 5, 286-296 DOI ScienceOn |
21 | Bell, S., Goldman, V.M., Bistrian, B.R., Arnold, A.H., Ostroff, G and Forse, R.A. (1999): Effect of beta-glucan from oats and yeast on serum lipids. Crit. Rev. Food Sci. Nutr., 39, 189-202 DOI ScienceOn |
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