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Cytotoxicity of Copper Nanoparticles in Cultured Human Bronchial Epithelial Cells (BEAS-2B)  

Park Eun-Jung (College of Pharmacy, Dongduk Women's University)
Park Kwangsik (College of Pharmacy, Dongduk Women's University)
Publication Information
Toxicological Research / v.21, no.4, 2005 , pp. 303-307 More about this Journal
Abstract
Nanomaterials, which ranges in size from 1 to 100 nm, have been used to create uqnique devices at the nanoscale level possessing novel physical and chemical functional properties. However, the toxicities of nanomaterials have not been fully tested and the risk of nanomaterials is emerging issues in these days. In this study, the cytotoxicity of copper nanoparticles was tested in cultured human bronchial epithelial cells. As a results, copper nanoparticles showed cytotoxicity similar with cupric ion and the apoptotic mechanisms of DNA fragmentation and caspase-3 activation were involved. Induction of heme oxygenase-1 and thioredoxin reductase by copper nanoparticles indicated that cytotoxicity of copper nanoparticles is likely to be mediated through oxidative stress.
Keywords
Copper nanoparticles; Cytotoxicity; Apoptosis; Heme oxygenase;
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