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Effects of Dietary Supplementation of Chitosan on the Metabolism of Lead in Rats  

권오덕 (경북대학교 수의과대학)
정규용 (원광대학교 의과대학)
Publication Information
Toxicological Research / v.19, no.4, 2003 , pp. 315-320 More about this Journal
Abstract
This study was carried out to investigate the effect of chitosan on lead metabolism in SD rats. Ten male rats were divided into a experimental group and a control group. Each experimental and control rats were administered by water contaminated with 100 mg/l of lead for 4 weeks, respectively. Experimental group received diets supplemented artificially with 5% of chitosan for 4 weeks. Body weight change, food and water consumption, fecal and urinary excretion, and fecal and urinary lead excretion were measured. There were no significant differences in body weight gain, food and water consumption, and fecal and urinary excretion between the two groups. However, fecal lead excretion of rats fed the diet containing 5% of chitosan were higher than the control group. Whereas urinary lead excretion of rats fed the diet containing 5% of chitosan were lower than the control group. The results suggested that the oral administration of chitosan prevents the gastrointestinal lead absorption in rats.
Keywords
Chitosan; Lead metabolism; Rat;
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