Browse > Article

Effect of APB-01 on the Ultraviolet-Induced Photoaging and Wrinkle Formation in the Hairless Mice  

이지해 ((주)태평양기술연구원 의약건강연구소)
이병석 ((주)태평양기술연구원 의약건강연구소)
변범선 ((주)태평양기술연구원 의약건강연구소)
김완기 ((주)태평양기술연구원 의약건강연구소)
이상준 ((주)태평양기술연구원 의약건강연구소)
심영철 ((주)태평양기술연구원 의약건강연구소)
김배환 ((주)태평양기술연구원 의약건강연구소)
Publication Information
Toxicological Research / v.19, no.4, 2003 , pp. 303-310 More about this Journal
Abstract
Ultraviolet (UV) is thought to induce erythema, sun-burn, photo-toxicity, photo-allergy, photo-aging and sometimes skin tumor. To investigate the photo-protective effects of APB-01 (Amore-Pacific Beauty-01, the mixture of Jaummi-dan and Fujiflavone P10) on UV-induced skin damage, forty of SKH hairless female mice were orally administered with APB-01 or saline fifth a week, and irradiated with UV third a week for up to ten weeks. We examined the relationship between visible changes and skin damage in the dermis and epidermis. In the APB-01 treated group, a better skin and less wrinkles formation were observed when compared to the UV control group. This results demonstrated that oral administration of APB-01 seems to have photo-protective effects on UV-induced skin damage of hairless mice due to an inhibitory effect on collagen breakdown, and the model using hairless mice is very useful to investigate the efficacy of functional beauty foods.
Keywords
APB-01; Jaummi-dan; Fujiflavone P10; Ultraviolet (UV); Photoaging; Hairless mice;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kligman, A.M. (1969): Early destructive effect of sunlight on human skin. J. Am. Med. Assoc., 210, 2377-2380   DOI   PUBMED   ScienceOn
2 Kligman, L.H., Sapadin, A.N. and Schwartz, E. (1996): Peeling agents and irritants, unlike tretinoin, do not stimulate collagen synthesis in the photoaqed hairless mouse. Arch. Dermatol. Res., 288, 615-620
3 Marta, J.P. (2001): Aging of the skin. The biology of the skin. Perthenon publishing. 209-218
4 Nishimori, Y., Edwards, C., Pearse, A., Matsumoto, K., Kawai, M. and Marks, R. (2001): Degenerative alterations of dermal collagen fiber bundles in photodamaged human skin and UV-irradiated hairless mouse skin: possible effect on decreasing skin mechanical properties and appearance of wrinkles. J. Invest. Dermatol., 117, 1458-1463
5 Stahl, W., Heinrich, U., Jungmann, H., Sies, H. and Tronnier, H. (2000): Carontenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am. J. Clin. Nutr., 71, 795-798
6 Scharffetter-Kochanek, K., Brenneisen, P. and Wenk, J. (2000): Photoaging of the skin form phenotype to mechanisms. Exp. Gerontol. 35, 307-316
7 Kaminer, M.S. (1995): Magnitude of the problem. In: Gilchrest BA, eds. Photodamage. Blackwell Science, Inc., 115
8 Hiroaki, M., Ichiro, K., Tomomi, S. and Toshio, I. (2001): Prevention of the photodamage in the hairless mouse dorsal skin by kojic acid as an iron chelator. Eur. J. Pharmacol., 411, 169-74   DOI   ScienceOn
9 Contet-Audonneau, J.L., Jeanmaire, C. and Paulty, G. (1999): A hitological study of human wrinkle structures: comparision between sun-exposed areas of the face, with or without wrinles, and sun-protected areas. Br. J. Dermatol., 140, 1038-1047
10 Record, I.R., Dreosti, I.E., Konstantinopoulos, M. and Buckley, R.A. (1991): The influence of topical and systemic vitamin E on ultraviolet light-induced skin damage in hairless mice. Nutr. Cancer, 16, 219-225
11 Montagna, W. and Carlisle, K. (1979): Structural changes in aging human skin. J. Invest. Dermatol., 73, 47-53   DOI   ScienceOn
12 Altman, D.G. (1993): Comparing groups-catedorical data: Practical stastics for Medical Research, Chapman & Hall, London, 229-276
13 Gilchrest, B., Szabo, G., Flynn, E. and RM G. (1983): Chronologic and actinically induced aging in human face skin. J. Invest. Dermatol., 80(8), 1S-85S.
14 Kim, S.Y., Ahn, D.K., Park, S.K., Lee, J.Y., Kim, W.G., Sim, Y.C. and Lee, S.J. (2002): Protective effects of jaummidan (Ciyinmei-dan) against skin photoaging in hairless mouse model and UVB-induced damage in human fibroblasts. J. Korean Oriental Med., 23, 43-53
15 Taylor, C.R., Stern, R.S., Leyden, J.J. and Gilchrest, B.A. (1990): Photoaging/photodamage and photoprotection. Arch. Dermatol., 22, 1-15
16 Epstein, J.H. (1983): Photocarcinogenesis, skin cancer, and aging. J. Am. Acad. Dermatol., 9, 487-502   DOI   PUBMED   ScienceOn
17 Moloney, S.J., Edmonds, S.H., Giddens, L.D. and Learn, D.B. (1992): The hairless mouse model of photoaging: evaluation of the relationship between dermal elastin, collagen, skin thickness and wrinkles. Photochem. Photobiol., 56, 505-511
18 Uitto, J., Fazio, M.J. and Olsen, D.R. (1989): Molecular mechanism of cutaneous aging. Age-associated connective tissue alterations in the dermis. J. Am. Acad. Dermatol., 21, 614-622   DOI   ScienceOn
19 Bisset, D.L., Hannon, D.P. and Orr, T.V. (1987): An animal model of solar-aged skin: histological, physical, and visible changes in UV-irradiated hairless mouse skin. Photochem. Photobiol., 46, 367-378
20 Fuchs, J., Huflejt, M.E., Rothfuss, L.M., Wilson, D.S., Carcamo, G. and Packer, L. (1989): Impairment of enzymic and nonenzymic antioxidants in skin by UVB irradiation. J. Invest. Dermatol., 93, 769-773   DOI   ScienceOn
21 Werninghaus, K., Meydani, M., Bhawan, J., Margolis, R., Blumberg, J.B. and Gilchrest, B.A. (1994): Evaluation of the photoprotective effect of oral vitamin E supplementation. Arch. Dermatol., 10, 1257-1261
22 Kligman, L.H., Akin, F.H. and Kligman, A.M. (1982): Prevention of ultraviolet damage to the dermis of hairless mice by sunscreens. J. Invest. Dermatol., 78, 181-189   DOI   ScienceOn
23 Boelsma, E., Hendriks, H. and Roza, L. (2001): Nutritional skin care: health effects of micronutrients and fatty acids. Am. J. Clin. Nitr., 73, 853-864
24 Katiyar, S.K. and Ahmad, N. (2000): Green Tea and Skin. Arch. Dermatol., 36, 989-994
25 Moan, J. and Dahlback, A. (1992): The relationship between skin cancers, solar radiation and ozone depletion. Br. J. Cancer, 65, 916-21
26 Kambayashi, H., Yamashita, M., Odake, Y., Takada, K., Funasaka, Y. and Ichihashi, M. (2001): Epidermal changes caused by chronic low-dose UV irradiation induce wrinkle formation in hairless mouse. J. Dermatol. Sci., 27, S19-S25
27 Varani, J., Spearman, D., Perone, P., Fligiel, S.E., Datta, S.C., Wang, Z.O., Shao, Y., Kang, S., Fishcer, G.J. and Voorhees, J.J. (2001): Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro. Am. J. Pathol., 158, 931-942
28 Eberlein-Konig, B., Placzek, M. and Przybilla, B. (1998): Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). J. Am. Acad. Dermatol., 38, 45-48   DOI   ScienceOn
29 Kligman, L.H. (1996): The hairless mouse model for photoaging. Clinics in Dermatology, 14, 183-195   DOI   PUBMED   ScienceOn