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Biomarker-Based Exposure to Phthalates and Related Factors with Demographics  

구정완 (가톨릭대학교 의과대학 예방의학교실 및 산업의학센터)
이강숙 (가톨릭대학교 의과대학 예방의학교실 및 산업의학센터)
박정일 (가톨릭대학교 의과대학 예방의학교실 및 산업의학센터)
구현정 (성균관대학교 약학대학 독성학 연구실)
이병무 (성균관대학교 약학대학 독성학 연구실)
Publication Information
Toxicological Research / v.19, no.4, 2003 , pp. 297-301 More about this Journal
Abstract
To investigate biomarker-based exposure to phthalates and related factors with demographics, 100 subjects who had participated in comprehensive health check-up were selected. We collected demographics through questionnaires and analyzed urine samples for 5 phthalates. Statistical likelihoods and regression methods were applied for data analysis using censored data. The highest levels of urine phthalates were 216$\mu\textrm{g}$/ml in di-isodecyl phthalate, 29.0$\mu\textrm{g}$/ml in di-butyl phthalate, 5.78$\mu\textrm{g}$/ml in di-(2-ethylhexyl) phthalate. The median values of di-(2-ethylhexyl) phthalate were 0.2340 $\mu\textrm{g}$/ml for male smokers, 0.0399 $\mu\textrm{g}$/ml for male non-smokers and 0.0085 $\mu\textrm{g}$/ml for female non-smokers, respectively. Di-(2-ethylhexyl) phthalate, benzyl butyl phthalate and di-isodecyl phthalate were higher in males than in females. In addition, mono-2-ethylhexyl phthalate was decreased with age. Our findings suggest that there might be significant demographic variations in exposure and/or metabolism of phthalates, and that health-risk assessment for phthalate exposure in humans should consider different potential risk groups.
Keywords
Phthalates; Demographics; Risk assessment.;
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