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Four Weeks Repeated Toxicity Study of 2-o-Benzoylcinnamaldehyde(CB-PH) by Oral Administration in Sprague-Dawley Rats  

조현무 (국립독성연구원)
성낙원 (국립독성연구원)
제정환 (국립독성연구원)
박기대 (국립독성연구원)
남기택 (국립독성연구원)
조완섭 (국립독성연구원)
한범석 (국립독성연구원)
양기화 (국립독성연구원)
김방현 (국립독성연구원)
Publication Information
Toxicological Research / v.19, no.4, 2003 , pp. 259-266 More about this Journal
Abstract
Although 'Cinnamon' has been widely used for the food and biophamacy in the world, it's toxicity was not screened completely. Major component of 'cinnamon' is CB-OH and CB-PH. CB-PH has been reported to have antimutagenic effect. To investigate the toxicity of 2-o-Benzoylcinnama-Idehyde (CB-PH), repeated dose (4 weeks) oral toxicity test performed in SD rats. Results of repeated dose oral toxicity tests for 4 weeks (CB-PH; 500, 1000, 2000 mg/kg/day) suggested that the CB-PH treated group showed no significant toxicological findings with body weights, organ weights, hematological and histopathological findings. Therefore, these data indicated that the maximum tolerated dose of CB-PH was 2000 mg above/kg/day in the rats.
Keywords
CB-PH; Repeated dose toxicity; Rats.;
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