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Subcutaneous Toxicity Study of Saposhnikovia divaricata (Turcz.) Schischk in Rats  

이영순 (서울대학교 수의과대학 공중보건학교실)
조성대 (서울대학교 수의과대학 공중보건학교실)
안남식 (서울대학교 수의과대학 공중보건학교실)
정지원 (서울대학교 수의과대학 공중보건학교실)
양세란 (서울대학교 수의과대학 공중보건학교실)
박준석 (서울대학교 수의과대학 공중보건학교실)
박기수 (서울대학교 수의과대학 공중보건학교실)
홍인선 (서울대학교 수의과대학 공중보건학교실)
서민수 (서울대학교 수의과대학 공중보건학교실)
Publication Information
Toxicological Research / v.19, no.1, 2003 , pp. 73-82 More about this Journal
Abstract
To evaluate influence of Saposhnikovia divaricata (Turcz.) Schischk extract on rat, Saposhnikovia divaricata (Turcz.) Schischk extract was diluted with 0.9% saline (100 mg/ml/kg, 10 mg/ml/kg, and 1 mg/ml/kg, respectively), and each of diluted test material extract was daily treated subcutaneously for 4 weeks and single-treated subcutaneously for 2 weeks. There were no significances in body weight analysis, urinary analysis, and ophthalmological test. However, in serum biochemical analysis and hematological analysis, we found some significances in high and middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by test material, because it was not found to be significant from control group in histopathological examination. Therefore, it was concluded that NOEL (No Observed Effect Level) of test material extract may be higher than all treatment doses used in this study, and Saposhnikovia divaricata (Turcz.) Schischk extract may be a non-toxic material.
Keywords
Saposhnikovia divaricata (Turcz.) Schischk; NOEL (No Observed Effect Level);
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1 Herbalogic studies on the chinese drug fang feng /
[ Zhong Yao Tong Bao ] / Zhongguo zhong Yao Za Zhi
2 GC-MS analysis of essential oils from the roots of Saposhnikovia divaricata (Turcz.) schischk /
[ Ji,L.;Pan,J.;Yang,J.;Xiao,Y. ] / Zhongguo Zhong Yao Za Zhi
3 Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium /
[ Wang,C.N.;Shiao,Y.J.;Kuo,Y.H.;Chen,C.C.;Lin,Y.L. ] / Planta Med   DOI   ScienceOn
4 Comparative studies on the febrifugal analgesic and anticonvulsive activities of water extracts from cultivated and wild Saposhnikovia divaricata /
[ Wang,F.R.;Xu,Q.P.;Li,P. ] / Zhong Xi Yi Jie He Za Zhi
5 Studies on chemical constituents from roots of Saposhnikovia divaricata (Turcz.), Schischk /
[ Xiao,Y.Q.;Li,L.;Yang,B.;huang,L.Q. ] / Zhongguo Zhong Yao Za Zhi
6 The major pectic arabinogalactan having activity on the reticuloendothelial system from the roots and rhizomes of Saposhnikovia divaricata /
[ Shimizu,N.;Tomoda,M.;Gonda,R.;Kanari,M.;Takanashi,N.;Takakhashi,N. ] / Chem Pharm Bull   DOI
7 Analgesic components of saposhnikovia root (Saposhnikovia divaricata) /
[ Okuyama,E.;Hasegawa,T;Matsushita,T.;Fujimoto,H.;Ishibashi,M.;Yamazaki,M. ] / Chem Pharm Bull   DOI   ScienceOn
8 Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: properties of umbelliferous or citrus crude drugs and their relative prescriptions /
[ Guo,L.Q.;Taniguchi,M.;Chen,Q.Y.;Baba,K.;Yamazoe,Y. ] / Jpn. J. Pharmacol   DOI
9 방풍수침(防風水鍼)이 진통 소염 해열 및 진경(鎭痙)에 미치는 영향 /
[ 강성길;이종국 ] / 대한침척학회지
10 Technics for cultivating Saposhnikovia divaricata /
[ Zhongguo;Zhong Yao;Za Zhi ] / Zhong Yao Tong Bao
11 방풍의 규격화에 관한 연구(A Study on The Standardization of Bang-Poong(방풍)) /
[ 이상인;서영배;최호영 ] / 경의한의대논문집
12 Pharmacologic studies on the root of Saposhnikovia divaricata (Turcz.) Schischk /
[ Tang,R.J.;Min,Z.H.;Xu,C.Y. ] / Zhong Yao Tong Bao