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A Teratogenicity Study on Dimethyl Dimethoxy Biphenylate Derivative (DDB-S) in Rats  

Kim, Hyun-Woo (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Park, Jin-Hong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Moon, Seo-Hyun (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Eu, Gook-Jong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Kim, Hwa (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Kim, Joon-Seong (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Park, Jong-Ha (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Cho, Hyun-Sun (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Kang, Ka-Mi (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Hwang, Seong-Hee (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Kim, Pan-Gyi (Laboratory of Environmental Health, College of National Science, Yongin University)
Moon, Jeon-Ok (Laboratory of Pharmaceutics, College of Pharmacy, Pusan National University)
Lee, Chi-Ho (Laboratory of Pharmaceutics, College of Pharmacy, Pusan National University)
Cho, Maing-Haing (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University)
Publication Information
Toxicological Research / v.19, no.1, 2003 , pp. 21-27 More about this Journal
Abstract
A teratogenic study of dimethyl dimethoxy biphenylate derivative (DDB-S) was carried out on Sprague-Dawley rats. DDB-S dissolved in saline was administered to male and female rats by intravenously injection at daily doses of 50 mg/kg, 75 mg/kg, and 100 mg/kg. A half of dams were sacrificed at 20th day of gestation to scrutinize the pregnant performances and fetal development. And the remaining dams were allowed to deliver. The growth, reflex, behaviour and reproductive function of F1 offsprings were examined. There was no treatment-related difference in body weight, food consumption and necropsy findings of dams. No gross, skeletal and visceral abnormalities was observed in F1 fetuses from dams treated with DDB-S. F1 offsprings did not show any treatment-related difference in growth, reflex, behaviour and reproductive performance. At caesarean section of F1 dams, no growth retardation and gross abnormality was observed in F2 fetuses. In conclusion, DDB-S did not show any potential teratogenic effect in rats.
Keywords
Dimethyl dimethoxy biphenylate derivative (DDB-S); Teratogenic study; Rats;
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  • Reference
1 의약품 등의 독성 시험 기준 /
[ 식품안전청 ] / 식품안전청 고시 제 1999-61호
2 Clianical effects of DDB pillules on 209 cases of viral hepatitis and cirrhosis /
[ Wang,C.F.;Chang,Y.X.;Chang,Y.L.;Yu,H.Q.;Shi,J.Y.;Fu,J.H.;Sun,F.;Zhou,J.Z.;Ge,W.J.;Chen,H.M.;Zheng,W.Y.;Miao,Z.Q.;Huang,J.D. ] / Beijing Med. J.
3 From the study of Fructus schizandrae to the discover of biphenyl dimethyl-dicarboxylate /
[ Liu,K.T. ] / Chem. Biol. Interact.
4 Biphenyl dicarboxylate in the treatment of viral hepatitis: results of 382 cases /
[ Wang,C.F.;Chang,Y.X.;Chang,Y.L.;Yu.H.Q.;Shi,J.Y.;Fu,J.H.;Sun,F.;Zhou,J.Z.;Ge,W.J.;Chen,H.M.;Zheng,W.Y.;Miao,Z.Q.;Huang,J.D. ] / Beijing Med. J.
5 Synthesis of Schizandrin C analogs /
[ Xie,J.X.;Zhou,J.;Zhang,C.Z.;Yang,J.H.;Chen,J.X.;Jin,H.Q. ] / Acta. Pharma. Sinica.
6 Therapeutic effects of DDB and traditional Chinese medicine on α-fetoprotein elevation of chronic viral hepatitis B and cirrhosis /
[ Chang,Y.X.;Yu,H.G.;Shi,J.Z.;Yong,A.L. ] / Beijing Med. J.
7 Observations on the effects of biphenyl dicarboxylate and honey-pilula of silyburn mariaimm(L), gaertn on chronic viral hepatitis /
[ Chang,Y.X.;Yu,H.G.;Shi,J.Z. ] / Chin. J. Modern Traditional Med.