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Developmental Immunotoxicity in SD Rat Pups Exposed by Di(n-butyl) Phthalate through Pre and Postnatal  

엄준호 (식품의약품안전청, 국립독성연구소 독성부)
정승태 (식품의약품안전청, 국립독성연구소 독성부)
이종권 (식품의약품안전청, 국립독성연구소 독성부)
박재현 (식품의약품안전청, 국립독성연구소 독성부)
권태우 (식품의약품안전청, 국립독성연구소 독성부)
김지영 (식품의약품안전청, 국립독성연구소 독성부)
오혜영 (식품의약품안전청, 국립독성연구소 독성부)
김형수 (식품의약품안전청, 국립독성연구소 독성부)
Publication Information
Toxicological Research / v.18, no.4, 2002 , pp. 401-409 More about this Journal
Abstract
Phthalate esters have possible effects on the endocrine system. Di-n-butyl phthalate (DBP) is one of the most commonly wed phthalic acid esters (PAEs). It is extensively wed as a plasticizer in elastomers, as a solvent for printing inks and resins, and as a textile lubricating agent. It is also present in the formulations of various cosmetic products. DBP has been identified as a reproductive toxicant in several animal species and also know as a endocrine disruptor. The objective of this study was to investigate the effect of DBP on developmental immune Junction wing rat pups as experimental animals. Timed-bred pregnant SD rats were orally dosed with 0, 250, 500, or 750 mg DBP/kg body weight once a day from gestational day (GD) 5 to 18 and postpartum day (PD) 3 to 18. On PD22, the dams and their pups were euthanized and examined for alteration in parameters associated to immune function. The results showed no significant changes in body weight, thymus weight, thymus and spleen cellularities, the polyclonal activation respones of splenocyte with ConA and LPS, and also the distribution of arterial blood cells and thymocyto subsets in both rat dam and pups. However DBP exposure on rat dam resulted in increases of liver weights of dam and their pups except 750 mg DBP/kg, and body and spleen weights in pups except 750 mg DBP/kg. On the other hands, distribution rates of CD8+ T cells at 500 mg DBP/kg and B cells at 750 mg DBP/kg among splenocyte subsets were significantly increased in rat pups, unlike dams. Reasons of these distribution alterations of CD8+ T cells and B cells in rat pups are under study.
Keywords
Di(n-butyl) phthalate (DBP); Gestational day (GD); Postpartum day; Developmental immunotoxicity;
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Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Nagarkatti PS. Enhanced activation-induced cell death as a mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity in peripheral T cells /
[ Camacho,I.A.;Hassuneh,M.R.;Nagarkatti,M. ] / Toxicology   DOI   ScienceOn
2 Both CD<TEX>$8^ +$</TEX> and CD<TEX>$16^ +$</TEX> human T cell clones can provide B cell help for immunoglobulin production /
[ Simonelli,C.;Rugiu,F.S.;Manetti,R.;Parronchi,P.;Piccinni,M.P.;Almerigogna,F.;Romagnani,S.;Maggi,E. ] / Int J. Clin. Lab. Res.   DOI   ScienceOn
3 Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog /
[ Cacalano,G.;Lee,J.;Kikly,K.;Ryan,A.M.;Pitts-Meek,S.;Hultgren,B.;Wood,W.I.;Moore,M.W. ] / Science   DOI
4 Human neutrophil migraton into skin chambers is associated with production of NAP-1/IL8 and C5a /
[ Follin,P.;Wymann,M.P.;Dewald,B.;Ceska,M.;Dahlgren,C. ] / Eur. J. Haematol.   DOI   ScienceOn
5 /
[ Agency for Toxic Substances and Disease Registry(ATSDR) ] / Toxicological Profile for Di-n-butylphthalate, TP-90-10
6 Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD 11b/CD 18 on humaan neutrophils /
[ Detmers,P.A.;Lo,S.K.;Olsen Egbert,E.;Walz,A.;Baggiolini,M.;Cohn,Z.A. ] / J. Exp. Med.
7 Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin:Ⅱ.Effects on the pup and the adult /
[ Gehrs.B.C.;Riddle,M.M.;Williams,W.C.;Smialowicz,R.J. ] / Toxicology   DOI   ScienceOn
8 Effect of Di(n-butyl) phthalate on the developing immune system of fetal and neonatal SD rats /
[ Chung,S.T.(et al.) ] / J. Toxicol. Pub. Health   과학기술학회마을
9 /
[ Long,G.;Meek,E. ] / Environmental Health Criteria 189:Di-n-Butyl phthalate
10 Developmental immnotoxicology /
[ Holladay,S.D.;Luster,M.I.;Kimmel,C.A.(ed.);Buelke Sam,J.(ed.) ] / Developmental Toxicology(2d ed)
11 Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults /
[ Dostal,L.A.;Chapin,R.E.;Stefanski,S.A.;Harris,M.W.;Schwetz,B.A. ] / Toxicol. Appl. Pharmacol.   DOI   ScienceOn
12 Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation /
[ Mychreest,E.;Wallace,D.G.;Fostre,P.M. ] / Toxicol Sci.   DOI   ScienceOn
13 Toward an integrated view of thymopoiesis /
[ Boyd,R.L.;Hugo,P. ] / Immunol. Today   DOI   ScienceOn
14 Developmental effects of endocrine-disrupting chemicals in wildlife and human /
[ Colborn,T.;vom Saal,F.;Soto,A. ] / Environ. Health Perspect
15 Interleukin 8(IL-8) selectively inhibits immunoglobulin E production induced by IL-4 in human B cells /
[ Kimata,H.;Yoshida,A.;Ishioka,C.;Lindley,I.;Mikawa,H. ] / J. Exp. Med.   DOI   ScienceOn
16 CD40 ligand-positive CD<TEX>$8^ +$</TEX> T cell clones allow B cell growth and differentiation /
[ Hermann,P.;Van Kooten,C.;Gaillard,C.;Banchereau,J.;Blanchard.D. ] / Eur. J. Immunol.   DOI   ScienceOn
17 A variety of environmentally persistent chemicals, including some phthalate plasicizers, are weakly estrogenic /
[ Jobling,S.;Reynolds,T.;White,R.;Parker,M.G.;Sumpter,J.P. ] / Environ. Health Perspect   DOI   ScienceOn
18 /
[ National Toxicology Program(NTP) ] / Final report on the reproductive toxicity of Di(n-buthyl) (CAS No. 84-74-2) In Sprague-Dawley Rats. NYIS Publication No. PB92111996
19 The estrogenic activity of phthalate esters in vitro /
[ Harris,C.A.;Henttu,P.;Parker,M.G.;Sumpter,J.P. ] / Environ. Health Perspect   DOI   ScienceOn
20 Further evaluation of developmental toxicity of di-n-butyl phthalate following administration during late pregnancy in rats /
[ Ema,M.;Miyawaki,E.;Kawashima,K. ] / Toxicol. Lett.   DOI
21 Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice:failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from muMT/muMT mice /
[ Homann,D.;Tishon,A.;Berger,D.P,;Weigle,W.O.;von Herrath,M.G.;Oldstone,M.B. ] / J. Virol.
22 Prenatal immunotoxicant exposure and postnatal autoinnume disease /
[ Holladay,S.D. ] / Environ. Health Perspect   DOI
23 Disruption of androgen-regulated male reproductive development by Di(n-butyl) phthalate during late gestation in rats is different from flutamide /
[ Mychreest,E.;Sar,M.;Cattley,R.C.;Foster,P.M. ] / Toxicol. Appl. Pharmacol.   DOI   ScienceOn
24 An essential role for antibody in neutrophil and eoxinophil recruitment to the cornea:B cell-deficient(microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis /
[ Hall,L.R.;Lass,J.H.;Diaconu.E.;Strine,E.R.;Pearlman,E. ] / J. Immunol.