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The Evaluation of Estrogenic/Antiandrogenic Activity of Puerariae Radix in Immature Rats Using Uterotrophic Assay and Hershberger Assay  

곽승준 (국립독성연구원 특수독성부)
김순선 (국립독성연구원 특수독성부)
이규식 (국립독성연구원 특수독성부)
손경희 (국립독성연구원 특수독성부)
김희연 (식품의약품안전청 식품평가부)
강길진 (식품의약품안전청 식품평가부)
최요우 (국립독성연구원 특수독성부)
박철훈 (국립독성연구원 특수독성부)
박귀례 (국립독성연구원 특수독성부)
Publication Information
Toxicological Research / v.18, no.4, 2002 , pp. 393-396 More about this Journal
Abstract
This study was carried out to evaluate the ostrogenic/antiandrogenic activity of Puerariae Radix in Sprague-Dawley rats. It has known that diverse phytoestrogen were included in some Puerariae Radix, especially in Pueraria mirifica. The Uterotrophic assay and Hershberger assay were performed to evaluate the ostogenic/antiandrogenic activity of various Puerariae Radix (Pueraria thunbergiana, Pueraria mirifica and Butea superba). In Uterotrophic assay, the extracts of Puerariae Radix were administered subcutaneously to immature female SD rats from 19 to 21 days of age. The wet uterus and vaginal weighs significantly increased in the group only treated with extracts of Pueraria mirifica. But, in Hersh-berger assay, all extracts of Puerariae Radix did not show any effects in the castrated rats. These results suggest that Pueraria mirifica has not undrogenic/antiandrogenic effect but potent estrogenic effect. It is possible that components of Pueraria mirifica may act as endocrine disruptor in human body.
Keywords
Puerariae Radix; Uterotrophic assay; Hershberger assay; Estrogenic activity; phytoestrogen; Endocrine disruptors;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
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