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Toxicokinetic Models and Data Interpretation  

유선동 (성균관대학교 약학부)
Publication Information
Toxicological Research / v.18, no.4, 2002 , pp. 311-324 More about this Journal
Abstract
Toxicokinetic studies are intended to provide critical evaluation of drug disposition at toxico-logical doses and help understand the relationship between blood or tissue levels and the time course of toxic events. Relatively high dose levels wed in toxicokinetics, compared to pharmacokinetics, complicates absorption, protein binding, metabolism and elimination processes. In this mini review, frequently wed toxicokinetic models such as linear compartment models, physiological models, and nonlinear kinetic mod-ec are introduced. In addition, optimization of toxicokinetic studies, their role in the drug development process, and prediction oj human toxicokinetics based on animal data by interspecies scaling are briefly discussed.
Keywords
Toxicokinetics; Pharmacokinetics; Compartment models; Physiological models; Nonlinear kinetics; Interspecies scaling;
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