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Resveratrol Induces the Apoptosis of Osteosarcoma Saos-2 Cells  

이현장 (원광대학교 의과대학 미생물학교실)
양재현 (원광대학교 의과대학 미생물학교실)
최익준 (원광대학교 의과대학 미생물학교실)
최이천 (원광대학교 의과대학 미생물학교실)
김용권 (원광대학교 의과대학 미생물학교실)
임창인 (원광대학교 의과대학 미생물학교실)
윤재도 (원광대학교 의과대학 미생물학교실)
김호찬 (원광대학교 의과대학 미생물학교실)
원진숙 (전북대학교 의과대학 생화학교실)
Publication Information
Toxicological Research / v.18, no.3, 2002 , pp. 259-265 More about this Journal
Abstract
Resveratrol, a phytoalexin found in grapes, berries, and peanuts, is one of the most promising agents for cancer prevention. Recent studies show that the antitumor activity of resveratrol occurs through p53-mediated apoptosis. This study demonstrated the mechanism that resveratrol induced apoptosis in human osteosarcoma Saos-2 cells lacking p53. Treatment of osteosarcoma Saos-2 cells with resveratrol resulted in decrease of cell viability, which was revealed as apoptosis characterized by activation of caspase-3 protease as well as cleavage of poly(ADP-ribose) polymerase (PARP) with change of mitochondrial membrane potential transition. These results suggest that resveratrol may be potentially useful to treat osteosarcoma via activation of caspase protease and mitochondrial dysfunction.
Keywords
Resveratrol; Osteosarcoma; p53; Apoptosis;
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  • Reference
1 Cell death: the significance of apoptosis /
[ Wyllie,A.H.;Kerr,J.F.;Currie,A.R. ] / Int. Rev. Cytol.   DOI
2 The therapy of osteogenic sarcoma: current status and thoughts for the future /
[ Friedman,M.A.;Carter,S.K. ] / Journal of Surgical Oncology   DOI   ScienceOn
3 Osteosarcoma /
[ Meyers,P.A.;Gorlick,R. ] / Pediatr Clin. North. Am.   DOI   ScienceOn
4 Antiproliferative effect of synthetic resveratrol on human breast epithelial cells /
[ Mgbonyebi,O.P.;Russo,J.;Russo,I.H. ] / Int. J. Oncol.
5 Prognostic factors in osteosarcoma:a critical /
[ Davis,A.M.;Bell,R.S.;Goodwin,P.J. ] / J. Clin. Oncol.   DOI
6 pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase /
[ Lauricella,M.;Calvaruso,G.;Carabillo,M.;D'anneo,A.;Giuliano,M.;Emanuels,S.;Vento,R.;Tesoriere,G. ] / FEBS Lett.   DOI
7 Resveratrol arrests the cell division cycle at S/G2 phase transition /
[ Ragione,F.D.;Cucciolla,V.;Borriello,A.;Pietra,V.D.;Racioppi,L.;Soldati,G.;Manna,C.;Galletti,P.;Zappia,V. ] / Biochem. Biophys. Res. Commun.   DOI   ScienceOn
8 p53, the cellular gatekeeper for growth and division /
[ Levine,A.J. ] / Cell.   DOI   ScienceOn
9 Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms /
[ Kim,Y.M.;Talanian,R.V.;Billiar,T.R. ] / J. Biol. Chem.   DOI   ScienceOn
10 Paclitaxel induces apoptosis in Saos-2 cells with CD95L upregulation and Bcl-2 phosphorylation /
[ Pucci,B.;Bellincampi,L.;Tafani,M. Masciullo,V.;Melino,G.;Giordano,A. ] / Exp. Cell. Res.   DOI   ScienceOn
11 Osteosarcoma associated with absent thumbs: a report of two cases /
[ Orme,L.;Gorlick,R.;Meyers,P.A.;Athanasian,E.;Huvos,A.G. ] / J. Pediatr. Hematol. Oncol.   DOI   ScienceOn
12 p53-dependent apoptosis modulates the cytotoxicity of anticancer agents /
[ Lowe,S.W.;Ruley,H.E.;Jacks,T.;Housman,D.E. ] / Cell.   DOI   ScienceOn
13 Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance /
[ Searle,J.;Kerr,J.F.;Bishop,C.J. ] / Pathol. annu.
14 Cancer chemopreventive activity of resveratrol /
[ Jang,M.;Pezzuto,J.M. ] / Drugs Exp. Clin. Res.
15 Apoptosis: the physiologic pathway of cell death /
[ Cohen,J.J. ] / Hosp Pract(Off Ed.)
16 Resveratrol-from the bottle to the bedside? /
[ Pervaiz,S. ] / Leuk. Lymphoma.   DOI
17 Cancer chemopreventive activity of resveratrol, a natural product derived from grapes /
[ Jang,M.;Cai,L.;Udeani,G.O.;Slowing,K.V.;Thomas,C.F.;Beecher,C.W.;fong,H.H.;Farnsworth,N.R.;Kinghorn,A.D.;Mehta,R.G.;Moon,R.C.;Pezzuto,J.M. ] / Science   DOI
18 Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage /
[ Sgambato,A.;Ardito,R.;Faraglia,B.;Boninsegna,A.;Wolf,F.I.;Cittadini,A. ] / Mutat. Res.   DOI
19 Resveratrol, a remarkable inhibitor of ribonucleotide reductase /
[ Fontecave,M.;Lepoivre,M.;Elleingand,E.;Gerez,C.;Guittet,O. ] / FEBS Lett.   DOI   ScienceOn
20 Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse /
[ Mahyar-Roemer,M.;Katsen,A.;Mestres,P.;Roemer,K. ] / Int. J. Cancer   DOI   ScienceOn
21 On the current management of osteosarcoma. A critical evaluaion and a proposal for a modified treatment strategy /
[ Bruland,O.S.;Pihl,A ] / Eur. J. Cancer   DOI   ScienceOn
22 p53 is required for radiation-induced apoptosis in mouse thymocytes /
[ Lowe,S.W.;Schmitt,E.M.;Smith,S.W.;Osborne,B.A.;Jacks,T. ] / Nature   DOI   ScienceOn
23 Apoptosis signaling by death receptors /
[ Schulze-Osthoff,K.;Ferrari,D.;Los,M.;Wesselborg,S.;Peter,M.E. ] / Eur. J. Biochem.   DOI   ScienceOn
24 Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-singnal-regulated protein kinases and p38 kinase /
[ She,Q.B.;Bode,A.M.;Ma,W.Y.;Chen,N.Y.;Dong,Z. ] / Cancer Res.