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Safety and Risk Assessment of 3-Monochloro-1,2-propanediol (3-MCPD)  

이병무 (성균관대학교 약학대학 독성학연구실)
Publication Information
Toxicological Research / v.18, no.1, 2002 , pp. 1-11 More about this Journal
Abstract
3-Monochloro-1,2-propanediol(3-MCPD) is currently being a matter of concern because of its toxicity. 3-MCPD produced during the acid hydrolysis of soybean products has been reported to be mutagenic, neurotoxic, nephrotoxic and spermatotoxic. Howerer, the carcinogenicity of 3-MCPD is a controversial issue over the past several decades. 3-MCPD characteristically showed a variety of toxicities in reproductive system such as, decrease in sperm number and sperm motility, infertility, loss of sperm function, and weight decrease in ovary. Due to the toxicity of 3-MCPD, exposure to 3-MCPD has been proposed to be reduced to as low a level as technologically feasible. 3-MCPD can be detected in soy sauce or non-soy sauce products. The legal limit for 3-MCPD this year has been suggested to be 20 ppb（$\mu\textrm{g}$/kg）in the European Community. In Korea, the permissible level of 3-MCPD is expected to be 0.3 ppm. In this study, 3-MCPD was toxicologically evaluated in terms of risk assessment in humans.
Keywords
3-Monochloro-1,2-propanediol (3-MCPD); Soybean sauce; Reproductive toxicity; Carcino-genicity; Risk assessment;
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1 Male genital cancers /
[ Gilliland,F.D.;Key,C.R. ] / Cancer   DOI
2 The oxidative metabolism of alpha- chlorohydrin in the male rat and the formation of spermatoceles /
[ Jones,A.R.;Milton,D.H.;Murcott,C. ] / Xeno-biotica
3 Synchronous assessment of sperm motility and fertilizing ability in the hamster following treatment with α-chlorohydrin /
[ Slott,V.L.;Jeffay,S.C.;Suarez,J.D.;Barbee,R.R.;Perreault,S.D. ] / J. Andrology
4 An extragonadal male antifertility agent /
[ Coppola J.A. ] / Life Sciences   DOI
5 The role of oxidative phosphorylation in the generation of ATP in human spermatozoa /
[ Ford,W.C.;Harrison,A. ] / J. Reprod. Fertil.   DOI
6 /
[ JECFA ] / Joint FAO/WHO Expert Committee an Food Additives Fifty-seventh meeting
7 The vicinal chloro-alcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster /
[ Frei,H.;Wurgler,F.E. ] / Mutation Research/Genetic Toxicology and Environmental Mutagenesis   DOI
8 Chlorohydrins in protein hydrolysates /
[ Velisek,J.;Davidek,J.;Hajslova,J.;Kubelka,V.;Janiceck,G.;Mankova,B.Z. ] / Zeitschrift fur Lebensmittel-Unter-suchungund-Forschung   DOI   ScienceOn
9 Salmonella mutagenicity tests: IV. Results form the testing of 300 chemicals Environ /
[ Zeiger,E.;Anderson,B.;Haworth,S.;Lawlor,T.;Mortelmans,K. ] / Mol. Mutagen.   DOI
10 The presence of glucose increases the lethal effects of α-chlorohydrin on ram and boar spermatozoa in vitro /
[ Ford,W.C.;Harrison,A. ] / J. Reprod. Fertil.   DOI
11 The entry of alpha- chlorohydrin into body fluids of male rats and its effect upon incorporation of glycerol into lipids /
[ Edwards E.M.;Jones A.R.;Waites G.M.H. ] / J. Reprod. Fert.   DOI   ScienceOn
12 Mechanism of inhibition of fructolysis in ram spermatozoa by chlorinated antifertility agents /
[ Reid,T.A.;Jones,A.R.;White,I.G. ] / Contraception   DOI   ScienceOn
13 Antifertility actions of α-chlorohydrin in the male /
[ Jones,A.R. ] / Aust. J. Biol. Sci.   DOI
14 The renal toxicity of the rodenticide α-chlorohydrin in the rat /
[ Jones,A.R.;Gadiel,P.;Murcott,C. ] / Naturwissenschaften   DOI   ScienceOn
15 Tumor incidences in Fischer 344 rats: NTP historical data /
[ Haseman,J.K.;Arnold,J.;Eustis,S.L.;G.A.Boorman(ed.);S.L.Euis(ed.);M.R.Elwell(ed.);C.A.Montgomery,Jr.(ed.);W.F.MacKenzie(ed.) ] / Pathology of the Fischer Rat: Reference and Atlas
16 Survey of 3-monochloropropane-1,2-diol in soysauce and similar products /
[ Jin,Q.;Zhang,Z.;Luo,R.;Li,J. ] / Wei Sheng Yan Jin
17 The metabolism of the soil fumigant 1,2-dibromo-3-chloropropane in the rat /
[ Jones,A.R.;Fakhouri,G.;Gadiel,P. ] / Experientia   DOI
18 /
[ Slater J.H.;C. Ratledge(ed.) ] / Microbial dehalogenation of haloaliphatic compounds
19 Possible mechanism of posttesticular antifertility action of 3-chloro-1,2-propanediol /
[ Gunn,S.A.;Gould,T.C.;Anderson,W.A.D. ] / Proc. Soc. Exptl. Biol. Med.   DOI
20 Mechanism of formation of chloropropanols present in protein hydrolysates /
[ Collier P.D.;Cromie D.D.O.;Davies A.P. ] / J. Assoc. Offic. Anal. Chem.
21 Chemosterilant and rodenticidal effects of 3-chloro-1, 2-propanediol (Epibloc) against the albino laboratory rat and the Nile field rat /
[ Helal,T.Y. ] / Int. Pest Control.
22 /
[ Hodgkinson,A. ] / Oxalic Acid in Biology and Medicine
23 A direct effect of α-chlorohydrin on motility and metabolism of ejaculated human spermatozoa /
[ Homonnai,Z.T.;Paz,G.;Sofer,A.;Yedwab,G.A.;Kraicer,P.F. ] / Contraception   DOI   ScienceOn
24 Identification of the biochemical lesion produced by α-chlorohydrin in spermatozoa /
[ Mohri,H.;Suter,D.A..I.;Brown-Woodman,P.D.C.;White,I.G.;Ridley,D. ] / Nature   DOI   ScienceOn
25 Characterization and antifertility activity in rats of S(+)-α-chlorohydrin /
[ Jackson,H.;Rooney,F.R.;Fitzpatrick,R.W.;Gibson,K.H. ] / Chemico-Biological Interactions   DOI   ScienceOn
26 Antifertility and dominant lethal mutation studies in male rats with dl-alpha-chlorohydrin and an amino-analogue /
[ Jones,P.;Jackson,H. ] / Contraception   DOI   ScienceOn
27 The anti-glycolytic action of (S)-α-chlorohydrin on epididymal bovine spermatozoa in vitro /
[ Jones,A.R.;du Toit,J.I. ] / Int. J. Androl.   DOI
28 Genotoxicity, metabolism and blood kinetics of epichloro-hydrin in mice /
[ Rossi A.M.;Migliore L.;Lascialfari D.;Sbrana I.;Loprieno N.;Tortoreto M;Bidoli F.;Panatarotto C. ] / Mutat. Res.   DOI   ScienceOn
29 Mutagenicity of helogenated and oxygenated three-carbon compounds /
[ Stolzenberg,S.J.;Hine,C.H. ] / J. Toxicol. Environ. Health   DOI
30 Carcinogenic activity of alkylating agents /
[ Van Duuren B.L.;Goldschmidt B.M.; Katz C.;Seidman C.K.;Paul J.S. ] / J. Natl. Cancer Inst.   DOI
31 Epoxides as obligatory intermediates in the metabolism of α-halohydrins /
[ Jones,A.R.;Fakhouri,G. ] / Xenobiotica   DOI   ScienceOn
32 Mutagenicity of chlorohydrins /
[ Ohkubo T.;Hayashi T.;Watanabe E.;Endo H.;Goto S.;Endo O.;Mizoguchi T.;Mori Y. ] / Nippon Suisan Gkkaishi
33 The neurotoxicity of α-chlorohydrin in rats and mice: Ⅱ.Lesion topography and factos in selective vulnerability in acute energy deprivation syndromes /
[ cavanagh J.B.;Nolan C.C.;Seville M.P. ] / Neuropathol. Appl. Neurobiol.   DOI   ScienceOn
34 Dibromochloropropane. Intent to suspend and conditionally suspend registrations of pesticide prodects /
[ Campt,D.D. ] / Fed. Registrar.
35 Effects of low doses of alpha-chlorohydrin on the dehydrogenases and oxidases of rat testis;A histochemical study /
[ Kaur S.;Guraya S.S. ] / Andrologia   DOI   ScienceOn
36 Alpha-chlorohydrin inhibits glyceraldehyde-3-phosphate dehydrogenase in multiple organs as well as in sperm /
[ Jelks,K.B.;Miller,M.G. ] / Toxicol. Sci.   DOI
37 The metabolism of 3-chloro, 3-bromo, and 3-iodopropan 1,2-diol in rats and mice /
[ Jones,A.R. ] / Xeno-biotica
38 The antifertility actions of α-chlorohydrin in the male /
[ Jones,A.R. ] / Life Sci.   DOI   ScienceOn
39 The neurotoxicity of alpha-chlorohydrin in rats and mice:I. Evolution of the cellular changes /
[ Cavnagh J.B.;Nolan C.C. ] / Neuropathol. Appl. Neurobiol.   DOI   ScienceOn
40 Glycerol α-monichlorohydrin /
[ Conant J.B.;Quayle O.R. ] / Organic Syntheses Collective
41 Mutagenicity o 2- and 3-carbon halogenated compounds in the Salmonella/mammalian microsome test /
[ Stolzenberg,S.J.;Hine,C.H. ] / Environmental Mutagenesis
42 Carcinogenicity tests of certain environmental and industrial chemicals /
[ Weisburger E.K.;Ulland B.M.;Nam J.;Gart J.J.;Weisburer J.H. ] / J. Natl. Cancer Inst.
43 Mutagenicity of chloropropanols in SOS Chromotest and Ames test /
[ Song,G.S.;Han,S.B.;Uhm,T.B.;Choi,D.S. ] / Korean J. Food Sci. Tech.
44 The antifertility and toxicity of alpha-chlorohydrin derivatives in male rats /
[ Brown-Woodman,P.D.;White,I.G.;Ridley,D.D. ] / Contraception   DOI   ScienceOn
45 The comparative effects of 1,2-dibromo-3-chloroproane(DBCP) and its metabolites, 3-chloro-1,2-propaneoxide (epich-lorohydrin), 3-chloro-1,2-propanediol (α-chlorohydrin), and oxalic acid, on the urogenital system of male rats /
[ Kluwe,W.M.;Gupta,B.N.;Lamb,J.C. ] / Toxicol. Appl. Pharmacol.   DOI   ScienceOn
46 Effects of α-chlorohydrin on epididymal sperm and epididymal plasma in swine /
[ Crabo B.G.;Zimmerman K.J.;Hunter A.G.;Graham E.F.;Moore R. ] / Arch. Andrology   DOI
47 Effect of α-chlorohydrin on metabolism and testosterone secretion by rat testicular interstitial cells /
[ Paz,G.;Carmon,A.;Homonnai,Z.T. ] / Int. J. Andrology   DOI
48 Effects of low doses of alpha-chlorohydrin on the dehydrogenases and oxidases of rat testis /
[ Kaur,S.;Guraya,S.S. ] / Andrologia   DOI   ScienceOn
49 Genotoxicity of 3-monochloropropane-1,2-diol /
[ FAC ] / Press Release 8/00 108th meeting of the Food Advisory Committee
50 Effect of alpha-chlorohysrin on rat sperm motions in relation to male reproductive functions /
[ Ban,Y.;Asanabe,U.;Inagaki,S.;Sasaki,M.;Nakatsuka,T.;Matsumoto,H. ] / J. Toxicol. Sci.   DOI
51 Detection of chemical mutagens by the dominant lethal assay in the mouse /
[ Epstein,S.S.;Arnold,E.;Andrea,J.;Bass,W.;Bishop,Y. ] / Toxicol. Appl. Pharmacol.   DOI   ScienceOn
52 Inhibition of fructolytic enzymes in boar spermatozoa by (S)-α-chlorohydrin and 1-chloro-3-hydroxypropanone /
[ Jones,A.R.;Bubb,W.A.;Murdoch,S.R.;Stevenson,D.A. ] / Aust. J. Biol. Sci.   DOI
53 The effects of domestic cooking on the levels of 3-monochloropropanediol in Foods /
[ Crew C.;Brereton P.;Davies A. ] / Food Addit. Contam.
54 Mechanism of antifertility activity of minimal dose level of alpha-chlorohydrin in the male rat /
[ Erickson,G.I.;Bennett,J.P. ] / Biol. Reprod.
55 Activities of various 6-chloro-6-deoxysugars and (S)-α-chlorohydrin in producing spermatocoeles in rats and paralysis in mice and in inhibiting glucose metabolism in bull spermatozoa in vitro /
[ Ford,W.C.;Waites,G.M. ] / J. Reprod. Fertil.   DOI
56 The action of (R)-and (S)-α-chlorohydrin and their metabolites /
[ Stevenson,D.;Jones,A.R. ] / Int. J. Andrology   DOI
57 3-monochloropropane- 1,2-diol (3-MCPD) in soy sauces and similar products available from retail outlets in the UK /
[ Macarthur R.;Crews C.;Davies A.;Brereton P.;Hough P.;Harvey D. ] / Contam.
58 The renal toxicity of some halogenated derivatives of propane in rats /
[ Jones,A.R.;Porter,K.;Stevenson,D. ] / Naturwissenschaften
59 The action of (S)-α-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa /
[ Jones,A.R.;Ford,S.A. ] / Contraception   DOI   ScienceOn
60 Sperm motion predicts fertility in male hamsters treated with alpha-chlorohydrin /
[ Slott,V.L.;Jeffay,S.C.;Dyer,C.J.;Barbee,R.R.;Perreault,S.D. ] / J. Androl.
61 An in vivo and in vitro investigation into the effects of α-chlorohydrin sperm motility and correlation with fertility in the Han Wistar rat /
[ Woods,J.;Garside,D.A. ] / Reproductive Toxicology   DOI   ScienceOn
62 Analytical methods for the determination of 3-chloro-1,2-propandiol and 2-chloro-1,3-propandiol in hydrolised vegetable protein, Seasonings and food products using gas chromatography/ion trap randem mass spectrometry /
[ Hamlet,C.G. ] / Food Addit. Contam.   DOI
63 Oxidative metabolic activity of boar spermatozoa: A system for assessing anti-glycolytic activity of potential inhibitors in vitro /
[ Jones,A.R.;Chantrill,L.A. ] / Reprod. Fertil. Dev.   DOI   ScienceOn
64 Carcinogenicity Study on 3-Monochloropropane-1,2-diol (3-MCPD) Administered in Drinking Water to Fischer 344 Rats /
[ Sunahara,G.;Perrin,I.;Marchessini,M. ] / Report RE-SR93003
65 A direct effect of α-chlorohydrin on rat epididymal spermatozoa /
[ Paz G.F.;Homonnai Z.T. ] / Int. J. Androl.   DOI
66 Significance of Leydig cell neoplasms in rats fed lactitol or lactose /
[ Bar A. ] / J. Am. Coll. Toxicol.
67 Distribution of 14C-alpha-chlorohydrin in mice and rats /
[ Crabo B.;Appelgren L.E. ] / J. Reprod. Fert.   DOI   ScienceOn
68 Effects of α-chlorohydrin upon the fertiling of spermatozoa of the cauda epididymis of the rat /
[ Turner,M.A. ] / J. Reprod. Fert.   DOI   ScienceOn
69 Effects of low doses of α-chlorohydrin on phosphatase, β-glucosidase, β-glucuronidase & hyaluronidase of rat testis & epididymis /
[ Gill,S.K.;Guraya,S.S. ] / Ind. J. Exp. Biol.
70 Inhibition of spermatogenesis in house rat (Rattus rattus Rufescens) following the administration of α-chlorohydrin /
[ Dixit W.P.;Agrawal M. ] / Andrologia   DOI   ScienceOn
71 Synergistic effects of α-chlorohydrin on the influence of copper ions on human spermatozoa /
[ Kalla,N.R.;Singh,B. ] / Int. J. Fertil.
72 Qualitative and quantitative changes of acid and alkaline phosphatases in the testis and epididymis of mice in relation to single high dose of α-chlorohydrin /
[ Sood P.P.;Majid M.A. ] / Acta Europaea Fertilitas
73 Analysis of 3-monochloropropane-1,2-diol(3-MCPD) /
[ Crew C.;Brereton P. ] / Lipid Technology
74 α-chlorohydrin induced changes in sperm fertilizing ability in the rat: association with diminished sperm ATP levels and motility Reprod /
[ Jelks,K.;Berger,T.;Horner,C.;Miller,M.G. ] / Toxicol.
75 Antifertility effects and metabolism of α- and epi-chlorohydrins in the rat /
[ Jones,A.R.;Davies,P.;Edwards,K.;Jackson,H. ] / Nature
76 Metabolism of three active analogues of the male antifertility agent α-chlorohydrin in the rat /
[ Jones,A.R.;O'Brien,R.W. ] / Xenobiotica   DOI   ScienceOn
77 Chemical inteference with sperm metabolic pathways /
[ Jones,A.R. ] / J. Reprod. Fertil. Suppl.
78 Qualitative and quantitative changes of acetylcholinesterase in the central nervous system of mice during low and high dose treatment of α-chlorohydrin /
[ Kakaria,V.K.;Sood,P.P. ] / Cell. Mol. Biol.
79 Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates /
[ Silhankova,L.;Smid,F.;Cerna,M.;Davidek,J.;Velisek,J. ] / Mutat. Res.   DOI   ScienceOn
80 Effects of short-term administration of α-chlorohydrin on reproductive toxicity parameters in male Sprague-Dawley rats /
[ Yamada T.;Inoue T.;Sato A.;Yamagishi K.;Sato M. ] / J. Toxicol. Sci.   DOI
81 Effects of alpha-chlorohydrin on in situ pH in rat testis and epididymis /
[ Caflisch C.R.;DuBose T.D. ] / Contraception   DOI   ScienceOn
82 Antifertility activity of α-chlorohydrin (3-chloro-1,2-propanediol, U-5897) on the female rats /
[ Lohika N.K.;Arya M. ] / Acta Eur. Fertil.
83 Glycosidase activity in epithelial cells isolated from normal and -chlorohydrin treated rats /
[ Kemp W.R.;Killian G.J. ] / Contraception   DOI   ScienceOn
84 In vivo and in vitro alkylation of testicular cysteine by α-chlorohydrin administration /
[ Kalla,N.R.;Bansal,M.P. ] / Ind. J. Exp. Biol.
85 Chloropropanols. In Toxicological Evaluation of Certain Food Additives and Contaminants /
[ Olsen,P. ] / Joint Expert Committee on Food Additives(41st Meeting) (WHO Food Additives Series)
86 Survival, body weight and spontaneous neoplasms in ad libitum-fed and food restricted Fischer F344 rats /
[ Thurman,J.D.;Bucci,T.J.;Hart,R.W.;Turturro,A. ] / Toxicol. Pathol.   DOI   ScienceOn
87 Futile substrate cycles in the glycolytic pathway of boar and rat spermatozoa and the effect of α-chlorohydrin /
[ Ford,W.C.;Harrison,A. ] / J. Reprod. Fertil.   DOI
88 Inhibition of glycolysis in boar sperm by α-chlorohydrin /
[ Hutton,P.;Dawson,A.G.;Jones,A.R. ] / Contraception   DOI   ScienceOn
89 The concerted effect of α-chlorohydrin and glucose on the ATP concentration in spermatozoa is associated with the accumulation of glycolytic intermediates /
[ Ford,W.C.;Harrison,A. ] / J. Reprod. Fertil.   DOI
90 Inhibition of glycolysis in boar spermatozoa by α-chlorohydrin phosphate appears to be mediated by phosphatase activity /
[ Jones,A.R.;Porter,L.M. ] / Reprod. Fertil. Dev.   DOI   ScienceOn
91 Antifertility activity of 3-chloro-1,2-propanediol (U-5897) on male rats /
[ Samojlik,E.;Chang,M.C. ] / Biol. Reprod.   DOI   ScienceOn
92 Utilization of a short-term male reproductive toxicity study design to examine effect of α-chlorohydrin(3-chloro-1,2-propanediol) /
[ Hoyt,J.A.;Fisher,L.F.;Hoffman,W.P.;Swisher,D.K.;Seyler,D.E. ] / Reprod. Toxicol.   DOI   ScienceOn
93 Dibromochloropropane;Intent to suspend and conditionally suspend registrations of pesticide prodects /
[ Campt D.D. ] / Fed. Registar.
94 /
[ European Comission ] / Official Journal
95 Conformational features of reduced and disulfide intact forms of hen egg white lysozyme in aqueous solution in presence of 3-chloro-1,2-propanediol and dioxane: implications for protein folding intermediates /
[ Sasidhar Y.U.;Pabha C.R. ] / Indian J. Biochem. Biophys.
96 Gonadotrophin changes in male rats following a sterilising does of α-chlorohydrin /
[ Morris,I.D.;Jackson,C.M. ] / Intern J. Androlog.   DOI
97 The effect of the isomers of α-chlorohydrin and rcemic β-chlorolactate in the rat kidney /
[ Porter K.E.;Jones A.R. ] / Chemico-Biological Interactions
98 Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrins contained in protein hydrolysates and commercial food /
[ Piasecki,A.;Ruge,A.;Marquard,H. ] / Arzneim. Forsch./Drug Res.
99 Determination of chloropropanols in protein hydrolysates /
[ Van Bergen,C.A.;Collier,P.D.;Cromie,D.D.O.;Lucas,R.A.;Preston,H.D.;Sissons,D.J. ] / J. Chromatogr.   DOI
100 Male antifertility compounds: biological properties of U-5897 and U-15, 646 /
[ Ericsson,R. J.;Baker,V.F. ] / J. Reprod. Fert.   DOI   ScienceOn
101 Effects of low deses of α-chlorohydrin in the dehydrogenases and oxidases of eat epididymal epithelium and sperms: a correlative histochemical and biochemical study /
[ Kaur,S.;Guraya,S.S. ] / Andrologia   DOI   ScienceOn