Echinacea purpurea extract inhibits LPS-induced inflammatory response by interfering with TLR4-mediated NF-κB and MAPKs signaling pathways |
Kim, Hae Lim
(NUON Co., Ltd.)
Min, Daeun (NUON Co., Ltd.) Lee, Sung-Kwon (NUON Co., Ltd.) Choi, Bong-Keun (NUON Co., Ltd.) Lee, Hae Jin (NUON Co., Ltd.) Lee, Dong-Ryung (NUON Co., Ltd.) |
1 | Zhao G, Wu H, Jiang K, Chen X, Wang X, Qiu C, et al. The anti-inflammatory effects of interferon tau by suppressing NF-κB/MMP9 in macrophages stimulated with Staphylococcus aureus. J Interferon Cytokine Res. 2016;36(8):516-24. DOI |
2 | Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 2010;72:219-46. DOI |
3 | Swantek JL, Cobb MH, Geppert TD. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Mol Cell Biol. 1997;17(11):6274-82. DOI |
4 | Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV. TRAF6 is a signal transducer for interleukin-1. Nature. 1996;383(6599):443-6. DOI |
5 | Jadhav T, Geetha T, Jiang J, Wooten MW. Identification of a consensus site for TRAF6/p62 polyubiquitination. Biochem Biophys Res Commun. 2008;371(3):521-4. DOI |
6 | Yang K, Zhu J, Sun S, Tang Y, Zhang B, Diao L, et al. The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination. Biochem Biophys Res Commun. 2004;324(1):432-9. DOI |
7 | Maruthamuthu V, Henry LJK, Ramar MK, Kandasamy R. Myxopyrum serratulum ameliorates airway inflammation in LPS-stimulated RAW 264.7 macrophages and OVA-induced murine model of allergic asthma. J Ethnopharmacol 2020;255:112369. DOI |
8 | Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 1999;13(8):1015-24. DOI |
9 | Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, et al. IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400. Mol Cell Biol. 2012;32(22):4684-90. DOI |
10 | Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFκB. J Biol Chem. 2001;276(45):41661-7. DOI |
11 | Chiu YH, Zhao M, Chen ZJ. Ubiquitin in NF-κB Signaling. Chem Rev. 2009;109(4):1549-60. DOI |
12 | Zhimin L, Tony H. Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem. 2009;78:435-75. DOI |
13 | Wang T, Hou W, Fu Z. Preventative effect of OMZ-SPT on lipopolysaccharide-induced acute lung injury and inflammation via nuclear factor-kappa B signaling in mice. Biochem Biophys Res Commun. 2017;485(2):284-9. DOI |
14 | Weinstein SL, Sanghera JS, Lemke K, DeFranco AL, Pelech SL. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem. 1992;267(21):14955-62. DOI |
15 | Barton GM. A calculated response: control of inflammation by the innate immune system. Journal Clin Investg. 2008;118(2):413-20. DOI |
16 | Beutler B. Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol. 2000;12(1):20-6. DOI |
17 | Ghosh S, May MJ, Kopp EB. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol. 1998;16(1):225-60. DOI |
18 | Kumar KM, Ramaiah S. Pharmacological importance of Echinacea purpurea. Int J Pharma Bio Sci. 2011;2(4):304-14. |
19 | Rao KMK. MAP kinase activation in macrophages. J Leukoc Biol. 2001;69(1):3-10. DOI |
20 | Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta Mol Basis Dis. 2010;1802(4):396-405. DOI |
21 | Woelkart K, Linde K, Bauer R. Echinacea for preventing and treating the common cold. Planta Med. 2008;74(06):633-7. DOI |
22 | Axen A, Carlsson A, Engstrom A, Bennich H. Gloverin, an antibacterial protein from the immune hemolymph of Hyalophora pupae. Eur J Biochem. 1997;247(2):614-619. DOI |
23 | Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428-35. DOI |
24 | Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016;7(36):58405. DOI |
25 | Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat Res-Fundam Mol Mech Mutagen. 2001;480:243-68. DOI |
26 | Gil A, Aguilera CM, Gil-Campos M, Canete R. Altered signalling and gene expression associated with the immune system and the inflammatory response in obesity. Br J Nutr. 2007;98(S1):S121-6. DOI |
27 | Sanghera JS, Weinstein SL, Aluwalia M, Girn J, Pelech SL. Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages. J Immunol. 1996;156(11):4457-65. DOI |
28 | Cheon SY, Chung KS, Jeon E, Nugroho A, Park HJ, An HJ. Anti-inflammatory activity of saxifragin via inhibition of NF-κB involves caspase-1 activation. J Nat Prod. 2015;78(7):1579-85. DOI |
29 | Medzhitov R, Janeway JrC. Innate immunity. N Engl J Med. 2000;343(5):338-44. DOI |
30 | Medzhitov R, Janeway JrC. Innate immune recognition: mechanisms and pathways. Immunol Rev. 2000;173:89-97. DOI |
31 | Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine 2008;42(2):145-51. DOI |
32 | Janeway JrCA, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20(1):197-216. DOI |
33 | Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev. 1995;9(22):2723-35. DOI |
34 | Craig WJ. Health-promoting properties of common herbs. Am J Clin Nutr. 1999;70(3):491s-99s. DOI |
35 | Yamada K, Hung P, Park TK, Park PJ, Lim BO. A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi. J Ethnopharmaco. 2011;137(1):231-5. DOI |
36 | Park BS, Lee JO. Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp Mol Med. 2013;45(12):e66. DOI |
37 | Chen CC, Wang JK. p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages. Mol Pharmacol. 1999;55(3):481-8. |
38 | Janeway CA. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol. 1989;54:1-13. DOI |
39 | Scott MG, Gold MR, Hancock RE. Interaction of cationic peptides with lipoteichoic acid and gram-positive bacteria. Infect Immun. 1999;67(12):6445-53. DOI |
40 | Arthur JSC, Ley SC. Mitogen-activated protein kinases in innate immunity. Nat Rev Immunol. 2013;13(9):679-92. DOI |
41 | Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine. 2008;42(2):145-51. DOI |
42 | Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282(5396):2085-8. DOI |
43 | Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999;13(10):1297-1308. DOI |
![]() |