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http://dx.doi.org/10.15188/kjopp.2020.02.34.1.1

Arctii Lappa Fructus Extract Induces Lipogenesis through SREBP-1 Activation of Sebocytes  

In, Myung Hee (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University)
Mun, Yeun Ja (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University)
Woo, Won Hong (College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.34, no.1, 2020 , pp. 1-6 More about this Journal
Abstract
Arctii Lappa Fructus has the numerous health benefits, including antioxidant, anti-inflammatory, and anti-carcinogenic properties. Skin lipids are one of several factors that maintain epidermal barrier function. This study was to explore the lipogenic effect by ethanol extract of Arctii Lappa Fructus (EAF) in sebocytes. First, it was confirmed that EAF exhibited high antioxidant activity and collagenase activity inhibition. We found that cholesterol and triglyceride levels of cells by EAF were increased significantly in a dose-dependent manner. Moreover, EAF increased the expression of transcription factor sterol regulatory element-binding protein-1 (SREBP-1) in the cells. These results suggest that EAF induces lipogenesis in cells through the activation of SREBP-1.
Keywords
Arctii Lappa Fructus; Cholesterol; Triglyceride; SREBP-1; Sebocyte;
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Times Cited By KSCI : 4  (Citation Analysis)
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