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http://dx.doi.org/10.15188/kjopp.2019.12.33.6.349

Anti-oxidative and Whitening Efects of 4'-O-methylalpinumisoflavone Isolated from Fruit of Maclura Tricuspidata Carrière  

Lyu, Ji Hyo (Division of Pharmacology, School of Korean Medicine, Pusan National University)
Noh, Joon Yong (Division of Pharmacology, School of Korean Medicine, Pusan National University)
Kim, Sura (Bio R&D Center, Sewonbiotech)
Lee, Guem San (Department of Herbology, College of Korean Medicine, Wonkwang University)
Lee, Dongho (Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University)
Kim, Koanhoi (Department of Pharmacology, School of Medicine, Pusan National University)
Kim, Hyungwoo (Division of Pharmacology, School of Korean Medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.33, no.6, 2019 , pp. 349-355 More about this Journal
Abstract
The anti-inflammatory effects of 4'-O-methylalpinumisoflavone (OMAI) has been reported in recent years. To develop effective and safe skin whitening agents, we investigated the anti-oxidative and melanogenic effects of OMAI isolated from fruit of Maclura tricuspidata Carrière (Cudrania tricuspidata) in macrophage and melanoma cell lines. In our results, OMAI showed effective superoxide scavenging activity and suppressed production of lipopolysaccharide (LPS)-induced intracellular reactive oxygen species (ROS) in RAW264.7 cells. In addition, α-melanocyte stimulation hormone (MSH)-induced production of melanin was also reduced by OMAI in B16F10 cells. Finally, OMAI significantly inhibited tyrosinase activity in B16F10 cells. These results suggest that OMAI suppressed melanin production via scavenging reactive oxygen species and inhibition of tyrosinase activity.
Keywords
Maclura tricuspidata; 4'-O-methylalpinumisoflavone; Anti-oxidant; Melanin; Tyrosinase;
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