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http://dx.doi.org/10.15188/kjopp.2019.10.33.5.282

Anti-Obesity Effects of Mixture of Atractylodes macrocephala and Amomum villosum Extracts  

Kim, Ha Rim (Department of Physiology, School of Korean Medicine, Wonkwang University & Ilwonbio Co., Ltd.)
Choi, Bong Keun (NutraPharm Tech Co., Ltd.)
Jung, Hyun Jong (Department of Diagnostics, School of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.33, no.5, 2019 , pp. 282-287 More about this Journal
Abstract
In this study, we investigated the anti-obesity effects of various mixtures of Atractylodes macrocephala (AM) and Amomum villosum (AV) water extracts on high-fat diet (HFD) induced mouse model. We classified five groups as follows; control, HFD, HFD + AM extracts : AV extracts (100mg/kg) (1:1), HFD + AM extracts : AV extracts (100mg/kg) (2:1), HFD + AM extracts : AV extracts (100mg/kg) (3:1). Oral administration of various mixtures of AM and AV extracts for 6 weeks inhibited HFD-induced increases of body, liver and epididymal fat weights. Also, lipid profiles including LDL cholesterol were improved by various mixtures of AM and AV extracts treatment compared with HFD-fed group. Lipogenesis-related genes such as acetyl coA carboxylase (ACC) and fatty acid synthase (FAS) in liver changed in a favorable way for lipid biosynthesis by HFD compared to control, but various mixtures of AM and AV extracts-treated groups did not. Our results show that various mixtures of AM and AV extracts can prevent HFD-induced obesity in mice and suggests that the mechanisms are involved in expressions and modifications of lipogenesis-related genes such as ACC and FAS in liver.
Keywords
Atractylodes macrocephala; Amomum villosum; Obesity; ACC; FAS;
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Times Cited By KSCI : 5  (Citation Analysis)
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