Browse > Article
http://dx.doi.org/10.15188/kjopp.2019.04.33.2.141

Yeosin-san Increases Female Fertility through Inducing Uterine Receptivity and Ovarian Function  

Choi, Hee Jung (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Joo, Bo Sun (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Park, Mi Ju (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Park, Min Jung (Korea Institution for Public Sperm Bank)
Bae, Boram (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Kim, Bo Sung (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Park, Hye Rin (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Kim, Keuk Jun (Department of Biomedical Laboratory Science, DaeKyeung University)
Yang, Hee Jin (CHO-A Pharm. CO., LTD.)
Yoo, Jeong Eun (Department of Korean Medical Gynecology, College of Korean Medicine, Daejeon University)
Chung, Tae Wook (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Joo, Jongkil (Department of Obstetrics and Gynecology, School of Medicine, Pusan National University Hospital)
Ha, Ki Tae (Korean Medical Research Center for Healthy Aging and School of Korean Medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.33, no.2, 2019 , pp. 141-150 More about this Journal
Abstract
Despite the development of assisted reproduction technologies (ART) including in vitro fertilization (IVF), the poor ovarian response and endometrial receptivity remains clinically a major unmet need. Although these problems are difficulties to solve in infertility treatment, there are no good therapeutic option yet. Traditional herbal remedies and acupuncture, therefore are being proposed as alternative treatment. Our group found that traditional herbal medicines such as Paeonia lactiflora L.(PL, 芍藥), Cyperus rotundus L.(CR, 香附子), and Perilla frutescens (PF, 紫蘇葉) could improve endometrial receptivity. In this study, we found out Yeosin-san (如神散) as an optimal herbal formula via combination of the previously established herbal medicines. Yeosin-san is a traditional Korean medical formula which was established by Ziming Jin (陳自明) and recorded in Furendaiquanliangfang (婦人大全良方) at first. The formula traditionally used for treating abnormal uterine bleeding and leukorrhea. It showed a highest effect on leukemia inhibitory factor (LIF) expression and on the adhesion between trophoblastic cells and endometrial cells. In addition, it has been shown that the Yeosin-san not only increases the endometrial receptivity to improve the embryo implantation but also enhances the ovary function by expressing the angiogenesis-related genes. Here we suggest that Yeosin-san could be a novel and effective candidate for treating female infertility.
Keywords
Yeosin-san; Fertility; Embryo implantation; Cell adhesion; Leukemia inhibitory factor (LIF);
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Gameiro S, Finnigan A. Long-term adjustment to unmet parenthood goals following ART: a systematic review and meta-analysis. Hum Reprod Update. 2017;23(3):322-37.   DOI
2 Valdes CT, Schutt A, Simon C. Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium. Fertil Steril. 2017;108(1):15-8.   DOI
3 de Ziegler D, Streuli I, Meldrum DR, Chapron C. The value of growth hormone supplements in ART for poor ovarian responders. Fertil Steril. 2011;96(5):1069-76.   DOI
4 Miravet-Valenciano JA, Rincon-Bertolin A, Vilella F, Simon C. Understanding and improving endometrial receptivity. Curr Opin Obstet Gynecol. 2015;27(3):187-92.   DOI
5 Huang Y, Hu C, Ye H, Luo R, Fu X, Li X, Huang J, Chen W, Zheng Y. Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency. J Immunol Res. 2019;2019:8069898.
6 Rajabi Z, Aliakbari F, Yazdekhasti H. Female Fertility Preservation, Clinical and Experimental Options. J Reprod Infertil. 2018;19(3):125-32.
7 Huang ST, Chen AP. Traditional Chinese medicine and infertility. Curr Opin Obstet Gynecol. 2008;20(3):211-5.   DOI
8 Xia JF, Inagaki Y, Zhang JF, Wang L, Song PP. Chinese medicine as complementary therapy for female infertility. Chin J Integr Med. 2017;23(4):245-52.   DOI
9 Lin J, Li XL, Song H, Li Q, Wang MY, Qiu XM, Li DJ, Wang L. A General Description for Chinese Medicine in Treating Premature Ovarian Failure. Chin J Integr Med. 2017;23(2):91-7.   DOI
10 Zeyneloglu HB, Onalan G. Remedies for recurrent implantation failure. Semin Reprod Med. 2014;32(4):297-305.   DOI
11 Yu N, Yang J, Yin T. Extracts from a traditional Chinese herbal remedy (Zhuyun recipe) improve endometrial receptivity in mice with embryonic implantation dysfunction and ovulation stimulation. J Ethnopharmacol. 2011;137(1):389-95.   DOI
12 Zhang M, Huang Y, Zhu G, Huang G, Dong L, Zhang J. Effect of Bushenantai recipe on the expression of endometrial LIF in mice with embryonic implantation dysfunction. J Huazhong Univ Sci Technolog Med Sci. 2008;28(1):65-8.   DOI
13 Choi HJ, Chung TW, Park MJ, Kim HS, You S, Lee MS, Joo BS, Lee KS, Kim KJ, Wee G, Kim CY, Kim CH, Ha KT. Benzoic Acid Enhances Embryo Implantation through LIF-Dependent Expression of Integrin alphaVbeta3 and alphaVbeta5. J Microbiol Biotechnol. 2017;27(4):668-77.   DOI
14 Gui J, Xiong F, Yang W, Li J, Huang G. Effects of acupuncture on LIF and IL-12 in rats of implantation failure. Am J Reprod Immunol. 2012;67(5):383-90.   DOI
15 Aghajanova L. Leukemia inhibitory factor and human embryo implantation. Ann N Y Acad Sci. 2004;1034:176-83.   DOI
16 Aghajanova L. Update on the role of leukemia inhibitory factor in assisted reproduction. Curr Opin Obstet Gyneco. 2010;22(3):213-9.   DOI
17 Choi HJ, Chung TW, Park MJ, Jung YS, Lee SO, Kim KJ, Ha KT. Water-extracted tubers of Cyperus rotundus L. enhance endometrial receptivity through leukemia inhibitory factor-mediated expression of integrin alphaVbeta3 and alphaVbeta5. J Ethnopharmacol. 2017;208:16-23.   DOI
18 Kim EY, Choi HJ, Chung TW, Choi JY, Kim HS, Jung YS, Lee SO, Ha KT. Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins. J Pharmacol Sci. 2016;131(4):259-66.   DOI
19 Choi HJ, Chung TW, Park MJ, Lee KS, Yoon Y, Kim HS, Lee JH, Kwon SM, Lee SO, Kim KJ, Baek JH, Ha KT. Paeonia lactiflora Enhances the Adhesion of Trophoblast to the Endometrium via Induction of Leukemia Inhibitory Factor Expression. PLoS One. 2016;11(2):e0148232.   DOI
20 Li S. Compendium of materia medica. Beijing: Foreign Languages Press, 2003.
21 Menkhorst E, Zhang JG, Sims NA, Morgan PO, Soo P, Poulton IJ, Metcalf D, Alexandrou E, Gresle M, Salamonsen LA, Butzkueven H, Nicola NA, Dimitriadis E. Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice. PLoS One. 2011;6(5):e19665.   DOI
22 Kim CM. Encyclopedia of Traditional Chinese Herbal Medicines (Korean Version). Seoul: Jungdam Publishing, 1997.
23 Aschenbach LC, Hester KE, McCann NC, Zhang JG, Dimitriadis E, Duffy DM. The LIF receptor antagonist PEGLA is effectively delivered to the uterine endometrium and blocks LIF activity in cynomolgus monkeys. Contraception. 2013;87(6):813-23.   DOI
24 Terakawa J, Wakitani S, Sugiyama M, Inoue N, Ohmori Y, Kiso Y, Hosaka YZ, Hondo E. Embryo implantation is blocked by intraperitoneal injection with anti-LIF antibody in mice. J Reprod Dev. 2011;57(6):700-7.   DOI
25 Jin Z. Furendaiquanliangfang. Beijng: People's Health Publishing, 2006.
26 Wang CH, Wang R, Cheng XM, He YQ, Wang ZT, Wu C, Cao J. Comparative pharmacokinetic study of paeoniflorin after oral administration of decoction of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats. J Ethnopharmacol. 2008;117(3):467-72.   DOI
27 Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018;62:2-10.   DOI
28 Hanson B, Johnstone E, Dorais J, Silver B, Peterson CM, Hotaling J. Female infertility, infertility-associated diagnoses, and comorbidities: a review. J Assist Reprod Genet. 2017;34(2):167-77.   DOI
29 Giess R, Tanasescu I, Steck T, Sendtner M. Leukaemia inhibitory factor gene mutations in infertile women. Mol Hum Reprod. 1999;5(6):581-6.   DOI
30 Arici A, Oral E, Bahtiyar O, Engin O, Seli E, Jones EE. Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells. Hum Reprod. 1997;12(6):1233-9.   DOI
31 Haidari K, Salehnia M, Rezazadeh Valojerdi M. The effect of leukemia inhibitory factor and coculture on the in vitro maturation and ultrastructure of vitrified and nonvitrified isolated mouse preantral follicles. Fertil Steril. 2008;90(6):2389-97.   DOI
32 Rizov M, Andreeva P, Dimova I. Molecular regulation and role of angiogenesis in reproduction. Taiwan J Obstet Gynecol. 2017;56(2):127-32.   DOI
33 Plendl J. Angiogenesis and vascular regression in the ovary. Anat Histol Embryol. 2000;29(5):257-66.   DOI
34 Cheng JG, Rodriguez CI, Stewart CL. Control of uterine receptivity and embryo implantation by steroid hormone regulation of LIF production and LIF receptor activity: towards a molecular understanding of "the window of implantation". Rev Endocr Metab Disord. 2002;3(2):119-26.   DOI
35 White CA, Zhang JG, Salamonsen LA, Baca M, Fairlie WD, Metcalf D, Nicola NA, Robb L, Dimitriadis E. Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy. Proc Natl Acad Sci U S A. 2007;104(49):19357-62.   DOI
36 Hu W, Feng Z, Teresky AK, Levine AJ. p53 regulates maternal reproduction through LIF. Nature. 2007;450(7170):721-4.   DOI
37 Steck T, Giess R, Suetterlin MW, Bolland M, Wiest S, Poehls UG, Dietl J. Leukaemia inhibitory factor (LIF) gene mutations in women with unexplained infertility and recurrent failure of implantation after IVF and embryo transfer. Eur J Obstet Gynecol Reprod Biol. 2004;112(1):69-73.   DOI
38 Henning RJ. Therapeutic angiogenesis: angiogenic growth factors for ischemic heart disease. Future Cardiol. 2016;12(5):585-99.   DOI
39 Ha CS, Joo BS, Kim SC, Joo JK, Kim HG, Lee KS. Estrogen administration during superovulation increases oocyte quality and expressions of vascular endothelial growth factor and nitric oxide synthase in the ovary. J Obstet Gynaecol Res. 2010;36(4):789-95.   DOI
40 Park MJ, Park SH, Lee SK, Moon SE, Moon HS, Joo BS. Expression of SDF-1alpha and leptin, and their effect on expression of angiogenic factors in mouse ovaries. Clin Exp Reprod Med. 2011;38(3):135-41.   DOI
41 Choi KH, Joo BS, Sun ST, Park MJ, Son JB, Joo JK, Lee KS. Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice. Fertil Steril. 2012;97(5):1234-41 e1-3.   DOI
42 Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544(7651):488-92.   DOI