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http://dx.doi.org/10.15188/kjopp.2017.02.31.1.59

Effects of Scutellaria baicalensis Extract on Skin Lesion of Contact Dermatitis induced by DNFB in Mice  

Yang, Beodul (School of Korean medicine, Pusan National University)
Kim, Sura (School of Korean medicine, Pusan National University)
Choi, Chan Hun (College of Korean Medicine, Dongshin University)
Jeoung, Hyun Woo (College of Korean Medicine, Dongshin University)
Kim, Hyungwoo (School of Korean medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.31, no.1, 2017 , pp. 59-64 More about this Journal
Abstract
Scutellaria baicalensis Georgi is one of major herbs used to treat patients with skin diseases diagnosed by wind-heat syndrome. This study was designed to investigate the effects of Scutellaria baicalensis Extract (SBE) on skin lesion of Contact dermatitis (CD) in mice. We investigated the effects of SBE on skin thickness, skin lesions, erythema index and melanin index in vivo. The effects on body weights and spleen/body weight ratio were also investigated in mice with CD induced by topical application of 1-Fluoro-2,4-dinitrofluorobenzene (DNFB). In our results, topical application of SBE lowered skin thickness significantly. In addition, SBE ameliorated skin lesions such as erythema, exudate and petechia in mice with CD. SBE also inhibited erythema index elevated by DNFB significantly. finally, SBE did not affect body weight and spleen/body weight ratio. In conclusion, these data imply that SBE can ameliorate skin lesion of CD such as erythema, exudate and petechia, and be used to treat CD patients with relative safety.
Keywords
Scutellaria baicalensis; Contact dermatitis; Skin lesion;
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Times Cited By KSCI : 2  (Citation Analysis)
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