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http://dx.doi.org/10.15188/kjopp.2017.02.31.1.46

Effects of KV Pharmacopuncture on MIA-induced Osteoarthritis Rat  

Park, Byung Jun (Young jin Korea Medical Clinic)
Choi, Hak Joo (Traditional and Biomedical Research Center (TBRC), Daejeon University)
Sim, Boo Yong (Traditional and Biomedical Research Center (TBRC), Daejeon University)
Yun, Mi Young (Department of Beuty Science, Kwangju Women's University)
Yoo, Ji Hyun (Department of Herbal Pharmaceutical Science, Joongbu University)
Kim, Dong Hee (Department of Pathology, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.31, no.1, 2017 , pp. 46-51 More about this Journal
Abstract
The aim of this study is to investigate anti-arthritis activity using a KV pharmacopuncture. KV pharmacopuncture was inserted at BL40 for 4 weeks to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 60 mg/ml. MMP-9, CTX II, LTB4, calcitonin and glycosaminoglycan level in serum were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Also, The histopathological change of knee was observed by H&E and safranin-O staining. Production of MMP-9, CTX II and LTB4 level in serum was decreased, respectively, in comparison with control. The other way, production of calcitonin and glycosaminoglycan level in serum was increased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the KV group showed a increase in the cartilage volume and proteoglycan. These results may be used a remedy for new korea medicine to ease the symptoms mentioned above.
Keywords
Bone metabolism; Korea medicine; KV pharmacopunture; MIA; Osteoarthritis; Remedy;
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