Browse > Article
http://dx.doi.org/10.15188/kjopp.2016.08.30.4.236

Study of Innate Immunity Suppression of Yeonsan Ogye listed on Dong-eui-bo-gam  

Choi, Hak Joo (Traditional and Biomedical Research Center (TBRC), Daejeon University)
Sim, Boo Yong (Traditional and Biomedical Research Center (TBRC), Daejeon University)
Joo, In Hwan (Department of Pathology, College of Korean Medicine, Daejeon University)
Yoo, Sun Kyun (Department of Food and Biotechnology, Joongbu University)
Kim, Dong Hee (Department of Pathology, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.30, no.4, 2016 , pp. 236-241 More about this Journal
Abstract
The aim of the study is to evaluate immune-enhancing effects of Yeonsan Ogye. Various extract of Yeonsan Ogye (200 and 400 mg/kg/daily) was treated orally to Balb/c mice for 1 week, before acute inflammation was induced by LPS. After cytokine (IFN-γ, TNF-α, IL-6, and IL-1β) and immune cells (white blood cell, neutrophil, lymphocyte, and monocyte) level by serum and blood were counted. As a result, Oral treatment of Yeonsan Ogye extract to the Balb/c mice were significantly decreased cytokine level in serum, in comparison with control group. in addition, production of white blood cell and monocyte in blood was decreased and granulocyte was increased respectively, in comparison with control. Our results demonstrated that Yeonsan Ogye extracts seem to have significant immune-enhancing. Thus, Yeonsan ogye may be developed as a raw material for new health food and medicine to ease the symptoms related with inflammatory and immune.
Keywords
Acute inflammation; Cytokine; Immune cells; Suppressrion of innate immunity; Yeonsan Ogye;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Chae, H.S., Ahn, C.N., Yoo, Y.M., Ham, J.S., Lee, J.M., Yoon, S.K., Choi, Y.I. The Effects of the High Pressure Boiled Extracts (HPBE) of the Ogol Chicken with Herbs on the Hormones, Cytokine, Specific Antibody of Serum in the Rat. Korean Journal for Food Science of Animal Resources. 24(3):283-292, 2004.
2 Kim, J.W., Sim, B.Y., Choi, H.J., Kim, D.H., The study on Biological Activities of Yeonsan Ogye listed on Dong-ui-bo-gam. Kor. J. Herbol. 30(5):23-28, 2015.   DOI
3 Kwon, H.G., Hwang, J.S., So, J.S., Lim, S.H. Immunological homeostasis and inflammatory immune disorders. The Korean Society for Molecular and Cellular Biology. 20(1):48-69, 2008.
4 Gonzalez-Rey, E., Chorny, A., Delgado, M. Regulation of immune tolerance by anti-inflammatory neuropeptides. Nature Reviews Immunology. 7(1):52-63, 2007.   DOI
5 Eun, J.S. Effect of Lespedeza Cuneata G. Don on the Activity of Murine Immune Cells. Korean J. Oriental Physiology & Pathology. 25(5):837-842, 2011.
6 Song, K.K., Park, M.Y., Choi, H.Y., Kim, J.D. Anticancer and Related Immunomodulatory and Anticachexic Effects of Insamyangyoung-tang Extracts on Non Small Cell Lung Carcinoma, NCI-H520, Xenograft Mice. Korean J. Oriental Physiology & Pathology. 27(1):63-77, 2013.
7 Park, G.B., Park, Y.C. Effects of Mahaenggamseok-tang-gagambang on Immune Cells and Cytokines in OVA-Induced Asthmatic Mice. Korean J. Oriental Physiology & Pathology. 23(3):590-598, 2009.
8 Choi, S.M., Lee, K.Y., Lee, H.S., Hong, J.H., Lee, M.H., Lee, B.C. A case of meningococcal meningitis with complement 9 deficiency. Korean Journal of Pediatrics. 48(1):101-103, 2005.
9 Lee, B.J., Yoon, S.Y., Park, H.W., Park, J.H., Cho, I.Y., Lee, J.S., Ryu, J.H. Effects of Concurrent Administration of Hyeolbuchukeo-tang and Aspirin on Atherosclerosis in the ApoE(-/-) Mouse. Journal of Korean Medicine. 32(1):164-174, 2011.
10 Lee, E.C. health behavior theory. Gyeonggi : YAS media, p 18, 2007.
11 Kim, J.G. Autoimmunity. Koran journal of pediatrics 50(12):1165-1172, 2007.   DOI
12 Byun, S.H., Yang, C.H., Kim, S.C. Inhibitory effect of Scrophulariae Radix extract on TNF-α, IL-1β, IL-6and nitric oxide production in lipopolysaccharide activated Raw 264.7 cells. The Korea Journal of Herbology. 20(2):7-16, 2005.
13 Mantovani, A. Cancer: inflaming metastasis. Nature. 457(7225):36-37, 2008.   DOI
14 Heo, J. DongEuiBoGam. Seoul : BubInBooks. pp 1065, 1858-1859, 2007.