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http://dx.doi.org/10.15188/kjopp.2016.08.30.4.229

Comparative Study for Anti-inflammatory and Anti-obesity Effect of Fractions from Leaf and Stem of Sasa Borealis  

Ha, You Bin (College of Korean Medicine, Dongguk University)
Park, Jae Hyoung (College of Korean Medicine, Dongguk University)
Jang, Jun Woo (Department of Pathology, College of Korean Medicine, Dongguk University)
Lim, Dong Woo (Department of Pathology, College of Korean Medicine, Dongguk University)
Kim, Jai Eun (Department of Pathology, College of Korean Medicine, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.30, no.4, 2016 , pp. 229-235 More about this Journal
Abstract
Sasa borealis has long been used in folk remedies and traditional Korean medicine for analgesic, sedative and anticarcinogenic purposes. To excavate novel natural compounds for treating obesity, we separated leaf and stem and fractionated. We screened phenolic contents, anti-oxidative and anti-inflammatory properties with the fractions. Dichloromethane (DCM) and ethyl acetate (EA) fraction from both leaf and stem exhibited high anti-oxidative properties demonstrated by DPPH, ABTS assay in accordance with their phenolic contents. In addition, DCM and EA fraction from leaf inhibited nitric oxide (NO) production as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in Raw 264.7 cell. Finally, DCM and EA fraction from both leaf and stem significantly inhibited 3T3-L1 preadipocyte differentiation and decreased intracellular lipid level. These results suggest that DCM and EA fraction from Sasa borealis may contain therapeutic agent for obesity by attenuating inflammation and oxidative stress.
Keywords
Sasa borealis; fraction; preadipocyte differentiation; ROS; iNOS; COX-2;
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Times Cited By KSCI : 4  (Citation Analysis)
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