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http://dx.doi.org/10.15188/kjopp.2016.04.30.2.95

Effects of the Water Extracts of Mantidis Ootheca, Rosa Laevigata, and Imperata Cylindrica on Blood Pressure in Renovascular Hypertension Induced by 2K1C  

Kim, Hye Yoom (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Ahn, You Mee (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Kho, Min Chul (Hanbang Body-fluid Research Center, Wonkwang University)
Park, Ji Hun (Hanbang Body-fluid Research Center, Wonkwang University)
Lee, Jae Yun (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University)
Lee, Soo Ho (Department of Korean Physiology, School of Korean Medicine, Wonkwang University)
Park, Sueng Hyuk (Department of Korean Physiology, School of Korean Medicine, Wonkwang University)
Kim, Byung Sook (Department of Hotel Culinary Arts & Nutrition, Jeonbuk Science College)
Kang, Dae Gill (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Lee, Yun Jung (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.30, no.2, 2016 , pp. 95-100 More about this Journal
Abstract
The aim of the present study is to investigate the hypotensive effect of Mantidis ootheca (WMO), Rosa laevigata (WIC), and Imperata cylindrica (WRL) in renovascular hypertension rats. Experimental hypertension model is 2-kidney and 1-clip (2K1C) induced rats. 2K1C rats were treated with WMO, WIC, and WRL at dose of 100 mg/kg/day orally for 3 weeks, respectively. Treatment groups with WMO, WIC, and WRL significantly lowered blood pressure. Interestingly, WMO, WIC, and WRL ameliorated endothelium-dependent and independent vascular relaxation in the phenylephrine-precontracted thoracic aorta in hypertension models. In addition, 2K1C-induced hypertension model increased plasma renin activity, however, WMO, WIC, and WRL attenuated those activities. These results suggest that WMO, WIC, and WRL ameliorates vascular dysfunction in 2K1C-induced hypertension models via the regulation of nitric oxide and renin-angiotensin-aldosterone system.
Keywords
Mantidis ootheca; Rosa laevigata; Imperata cylindrica; 2-kidney and 1-clip; Nitric oxide; Renovascular hypertension; Renin-angiotensin-aldosterone syste;
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