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http://dx.doi.org/10.15188/kjopp.2016.04.30.2.81

Effects of Leonurus Sibiricus L. Extract on Diet-induced Hypercholesterolemia in Rats  

Kim, Jeung Beum (Department of Pathology, College of Korean Medicine, Semyung University)
Kim, Tae Yeon (Department of Preventive Medicine, College of Korean Medicine, Semyung University)
Kang, Hee (Graduate School of East-West Medical Science, Kyung Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.30, no.2, 2016 , pp. 81-87 More about this Journal
Abstract
This study was performed to investigate the cholesterol-lowering effect of liquid extract from Leonurus sibiricus Linne (LS). SD rats were fed atherogenic diet for 6 weeks. During the experimental period, LS liquid extract (3 g/kg and 6 g/kg) was orally given to the rats. The liver weight and levels of total cholesterol, LDL-cholesterol, and triglycerides in serum were significantly increased in rats fed with atherogenic diets. Oral treatment of LS liquid extract to the rats fed atherogenic diet significantly reduced the liver weights and significantly decreased the levels of total cholesterol, LDL-cholesterol, and triglycerides. The level of serum HDL-cholesterol was significantly increased at a high dose group compared with rats fed normal diet chow. These results indicate that LS liquid extract has the potential to restore altered lipid profiles induced by cholesterol rich diets and prevent the development of atheroclerosis.
Keywords
Leonurus Sibiricus; Hyperlipidemia; Cholesterol; Atherosclerosis;
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1 Heron, M. Deaths: leading causes for 2010. National Vital Statistics Report 262(6):1-96, 2013.
2 Farmer, J.A., Gotto, A.M. Dyslipidemia and other risk factors for coronary artery disease. In:Braunwald, E.(Ed.), Heart disease, Saunders, Philadelphia, PA. pp 1126-1160, 1997.
3 Hegsted, D.M., McGandy, R.B., Myerrs, M.L., Stare, F.J. Quantitative effects of dietary fat on serum cholesterol in men. American Journal of Clinical Nutrition 17(5):281-295, 1965.   DOI
4 Daniels, T.F., Killinger, K.M., Michal, J.J., Wright, R.W., Jiang, Z. Lipoproteins, cholesterol homeostasis and cardiac health. International Journal of Biological Sciences 5(5):474-488, 2009.   DOI
5 Bang, H.J., Kang, Y.H. Literature Study on Hyperlipidemia in Oriental Medicine. The Journal of East-West Medicines 21(2):70-81, 1996.
6 Translated by Professors of Herbology in South Korea, Herbology, Seoul, Younglimsa, p 423, 2000.
7 Park, S.C., Na, H.M., Bae, Y.H., Cho, J., Na, C.S., Kim, J.S. The Effect of Leonurus sibiricus on uterine activity. Korean Journal of Animal Reproduction 19(4):245-250, 1996.
8 Lee, S.J., Kim, D.C., Baek, S.H. The effect of Leonurus sibiricus on the proliferation inhibition of human uterine Leiomyoma cell and expression of gene related cell apoptosis. The Journal of Oriental Obstetrics and Gynecology. 19(3):001-002, 2006.
9 Sheo, H.J., Kook, H.S., Lee, M.Y. Effects of Leonurus sibiricus extract on experimentally induced liver damage and alloxan diabetes in rabbits. Journal of the Korean Society of Food Science and Nutrition. 16(1):22-28, 1987.
10 Jung, Y.B., Kim, H.H., Lee, S.D., Ahn, D.K., Shin, H.S., Baek, T.H., Choi, H.Y. Effect of water extract of Leonuri Herba on Vasospasm in a Rat Femoral Artery Model. The Korean Journal of Herbology. 18(2):169-178, 2003.
11 Park, K.K., Ryu, J.W., Choi, E.K., Ro, H.S. Anti-hypertensive Effects of Pini Folium and Leonuri Herba Extract on Spontaneously Hypertensive Rat(SHR). The Journal of Applied Pharmacology. 8(1):27-31, 2000.
12 Friedewald, W.T., Levy, R.I., Fredicson, D.S. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18: 449-502, 1972.
13 Gylling, H.M. Mietinnen, T.A. Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. J Lipid Res 43: 1472-1458, 2002.   DOI
14 Goldstein, J.L., Brown, M.S. Regulation of the Mevalonate pathway. Nature 343(6257):425-430, 1990.   DOI
15 Wilson, P.W. Abbott, R.D., Castelli, W.P. High density lipoprotein cholestgerol and mortality. The Framingham Heart Study. Arteriosclerosis 8: 737-741, 1998.   DOI
16 Lundberg, A.M., Hansson, G.K. Innate immune signals in atherosclerosis. Clinical Immunology 134: 5-24, 2010.   DOI
17 Owens, A.P.3rd, Byrnes, J.R., Mackman, N. Hyperlipidemia, tissue factor, coagulation, and simvastatin. Trends in Cardiovascular Medicine 24(3):95-98, 2014.   DOI
18 Labreuche, J., Taboul, J.P., Amarenco, P. Plasma triglyceride levels and risk of stroke and carotid atherosclerosis: a systematic review of the epidemiological studies. Atherosclerosis. 203: 331-345, 2009.   DOI
19 Puccetti, L., Bruni, F., Bova, G., Cercignani, M., Pompella, G., Auteri, A., Pasqui A.L. Role of platelets in tissue factor expression by monocytes in normal and hypercholesterolemic subjects. In vitro effect of cervastatin. International Journal of Clinical Laboratory Research 30(3):147-156, 2000.   DOI
20 Ramasamy, I. Recent advances in physiological lipoprotein metabolism. Clinical Chemistry and Laboratory Medicine 52(12):1695-1727, 2014.   DOI
21 Freiberg, J.J., Tybjaerg-Hansen, A., Jensen, J.S., Nordetgaard, B.G. Nonfasting triglyceride triglycerides and risk of ischemic stroke in the general population. The Journal of the American Medical Association 300(18):2142-2152, 2008.   DOI
22 Seol, I.C., Kim, B.T. Effects of Kamiboyanghwanotang (KBHT) on hyperlipidemia, thrombosis, hyperviscosity, hypertension and brain damage. The Journal of Oriental Chronic Disease. 4(1):133-162, 1998.
23 Kim, Y.J., Yu, B.N., Kim, Y.S., Seol, I.C. The Effect of Dansamtongmek-tang and Dansamsengmek-san on Hyperlipidemia and Brain & Cell Damage by Hypoxia The Journal of Korean Oriental Medicne 27(3):107-131, 2006.
24 Hur, H., Kim, D.J., Byun, J.S., Choi, B.H. Hypolipidemic effect of 'Saengjinyanghyul-tang' water extract in the Streptozocin-induced hyperlipemic SD Rat. The Journal of Korean Oriental Internal Medicine 27(2):444-458, 2006.
25 Kang, S.S., Shin, Y.J., Jo, J.J., Jeon, S.Y. Study of the Effects of Samulhwalhyeol-tang in Hyperlipidemic Animal Model Induced with a High-Fat Diet. The Journal of Korean Oriental Internal Medicine 35(2):119-132, 2014.
26 Lee, S.G., Lee, S.S., Baek, J.W., Lee, S.J., Kim, K.H. Effect of Crataegill Fructus on Serum Lipid in High Cholesterol Diet Induced Hyperlipidemic Rats. The Journal of Society of Preventive Korean Medicine. 7(2):13-22, 2003.
27 Gong, T.H., Jeong, J.C. Effects of Ojung-hwan on Blood Glucose, Hyperlipidemia, Polyol Pathway and Antioxidative Mechanism in Ob/ob Mouse. The Journal of Korean Oriental Medicine 28(3):57-69, 2007.
28 Kim, M.S., Seo, I.B., Kim, J.B. Effets of Salviae Miltiorrhizae Radix on the Diet-induced Hyperlipidemia in Rats. Korean Journal Oriental Physiology & Pathology 18(2):431-435, 2004.
29 Shih, C.K., Lee, Y.J. Effects of Stephaniae Tetrandrae Rhizoma and Sinomenii Caulis on Hyperlipidemia in Rat. Korean Journal Oriental Physiology & Pathology 19(2):495-500, 2005.
30 Lee, Y.J., Sohn, Y.J., Lim, D.B., Lee, E.S., Park, J.S., Kim, S. Effects of Coicis Semen on The Hyperlipidemia Induced by Fructose-rich chow in Rat. The Korean Journal of Herbology. 20(1):85-92, 2005.
31 Shin, H.S., Kim, G.Y., Kim, H.H., Seo, I.B. Curative Effects of Typhae Pollen on the Diet-induced Hyperlipidemia in Rats. Korean Journal Oriental Physiology & Pathology 17(1):225-229, 2003.
32 Kim, H.S., Kim, M.A., Jang, S.H., Lee, W.K., Ryu, J.Y., Lee, S.K. Anti-hyperlipidemic Effects of Cordycepts militaris Hot-Water Extract. Journal of the Environmental Sciences 21(7):875-881, 2012.   DOI
33 Wu, J.H., Wang, Q.H., Li, F., Shu, Y.L., Chan, C.O., Mok, D.K., Chan, S.W. Suppression of diet-induced hypercholesterolemia by Turtle Jelly, A traditional Chinese Functional Food, in rats. Evidence-Based Complementary and Alternative Medicine. 2012: 320303, 2012.
34 Liu, X., Lee, J. The Conduct of Drug Metabolism Studies Considered Good Practice (I): Analytical Systems and In Vivo Studies. Current Drug Metabolism 8(8):815-821, 2007.   DOI
35 Chiang, M.T., Chen, Y.C., Huang, A.L. Plasma lipoprotein cholesterol levels in rats fed a diet enriched in cholesterol and cholic acid. International Journal for Vitamin and Nutrition Research. 68(5):328-334, 1998.
36 Kim, S.J., Han, H.S., Lee, Y.J. Effects of Leonuri Herba and Leonuri Semen on Hypercholesterolemia. Korean Journal of Herbology. 25(3):73-80, 2010.   DOI