Apoptosis of Human Bladder Cancer Cells by an Ethanolic Extract of Scutellaria Baicalensis GEORGI Via Caspase and MAPK Signaling Pathways |
Gim, Huijin
(Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine)
Shim, Ji Hwan (Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine) Lee, Soojin (Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine) Park, Hyun Soo (Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine) Kim, Byung Joo (Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine) |
1 | Lee, S.J., Kim, H.M., Cho, Y.H., Park, K., Kim, E.J., Jung, K.H., Kim, C.H., Kim, W.J., Moon, S.K. Aqueous extract of Magnolia officinalis mediates proliferative capacity, p21WAF1 expression and TNF-alpha-induced NF-kappaB activity in human urinary bladder cancer 5637 cells; involvement of p38 MAP kinase. Oncol Rep 18: 729-736, 2007. |
2 | Tang, W., Eisenbrand, G. Chinese drug of plant origin: chemistry, pharmacology and use in traditional and modern medicine. Springer-Verlag, Berlin. pp 919-929, 1992. |
3 | Kumagai, T., Muller, C.I., Desmond, J.C., Imai, Y., Heber, D., Koeffler, H.P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leukemia Res 31: 523-530, 2007. DOI |
4 | Yune, T.Y., Lee, J.Y., Cui, C.M., Kim, H.C., Oh, T.H. Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. J Neurochem 110: 1276-1287, 2009. DOI |
5 | Burnett, B.P., Jia, Q., Zhao, Y., Levy, R.M. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce in flammation. J Med Food 10: 442-451, 2007. DOI |
6 | Shin, H.S., Bae, M.J., Jung, S.Y., Shon, D.H. Preventive effects of skull cap (Scutellaria baicalensis) extract in a mouse model of food allergy. J Ethnopharmacol 153: 667-673, 2014. DOI |
7 | Saraste, A., Pulkki, K. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45: 528-537, 2000. DOI |
8 | Sheikh, M.S., Huang, Y. Death receptors as targets of cancer therapeutics. Curr Cancer Drug Targets 4: 97-104, 2004. DOI |
9 | Murphy, L.O., Blenis, J. MAPK signal specificity: the right place at the right time. Trends Biochem Sci 31: 268-275, 2006. DOI |
10 | Fan, M., Chambers, T.C. Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist Updat 4: 253-267, 2001. DOI |
11 | Chen, D., Yang, Z., Wang, Y., Zhu, G., Wang, X. Capsaicin induces cycle arrest by inhibiting cyclin-dependent-kinase in bladder carcinoma cells. Int J Urol 19: 662-668, 2012. DOI |
12 | Guo, Q., Li, J., Lin, H. Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment. Biomed Res Int 2015: 261620, 2015. |
13 | Li, J., Lin, H.S. Integrative medicine: a characteristic China model for cancer treatment. Chin J Integr Med 17: 243-245, 2011. DOI |
14 | Li, J., Li, L., Liu, R., Lin, H.S. Establishing Chinesemedicine characteristic tumor response evaluation system is the key to promote internationalization of Chinese medicine oncology. Chin J Integr Med 18: 730-736, 2012. DOI |
15 | National Pharmacopoeia Committee. Phamacopoeia of People's Republic of China. Medical Science and Technology Publishing House. Beijing. pp 159-160, 2010. |
16 | Li-Weber, M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev 35: 57-68, 2009. DOI |
17 | Zhang, N., Van Crombruggen, K., Holtappels, G., Bachert, C. A Herbal Composition of Scutellaria baicalensis and Eleutherococcus senticosus Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model. Evid Based Complement Altern Med 2012: 673145, 2012. |
18 | Guo, Q., Zhao, L., You, Q., Yang, Y., Gu, H., Song, G., Lu, N., Xin, J. Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Res 74: 16-24, 2007. DOI |
19 | Kowalczyk, E., Krzesinski, P., Kura, M., Niedworok, J., Kowalski, J., Błaszczyk, J. Pharmacological effects of flavonoids from Scutellaria baicalensis. Przegl Lek 63: 95-96, 2006. |
20 | Li, C., Lin, G., Zuo, Z. Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. Biopharm Drug Dispos 32: 427-445, 2011. DOI |
21 | Liao, J.F., Hung, W.Y., Chen, C.F. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. Eur J Pharmacol 464: 141-146, 2003. DOI |
22 | Zhang, Q., Zhao, S.H., Chen, J., Zhang, L.W. Application of ionic liquid-based microwave-assisted extraction of flavonoids from Scutellaria baicalensis Georgi.J Chromatogr B Analyt Technol Biomed Life Sci 1002: 411-417, 2015. DOI |
23 | Majno, G., Joris, I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146: 3-15, 1995. |
24 | Saraste, A., Pulkki, K. Morphologic and biochemical hallmarks of apoptosis. Cardiovasc Res 45: 528-537, 2000. DOI |
25 | Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F., Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139: 271-279, 1991. DOI |
26 | Hellein, K.N., Kennedy, E.M., Harwood, V.J., Gordon, K.V., Wang, S.Y., Lepo, J.E. A filter-based propidium monoazide technique to distinguish live from membrane-compromised microorganisms using quantitative PCR. J Microbiol Methods 89: 76-78, 2012. DOI |
27 | Wang, B.J., Won, S.J., Yu, Z.R., Su, C.L. Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide. Food Chem Toxicol 43: 543-552, 2005. DOI |
![]() |