Browse > Article
http://dx.doi.org/10.15188/kjopp.2016.02.30.1.40

Screening of Positive Inotropic Effect from Herbal Extracts in Beating Rabbit Atria  

Lee, Yun Jung (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Kwon, Oh Jeong (Hanbang Body-fluid Research Center, Wonkwang University)
Kim, Hye Yoom (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Namgung, Seung (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Lee, Jae Yun (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University)
Yu, Yun Cho (Department of Phygiology, College of Korean Medicine, Woosuk University)
Kang, Dae Gill (Department of Phygiology, College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.30, no.1, 2016 , pp. 40-46 More about this Journal
Abstract
Many medicinal plants have been used for the treatment of edema, jaundice, and gonorrhea in traditional Oriental medicine. This screening study was designed to search the positive inotropic effects of herbal extracts in beating rabbit atria. Aquarius extracts of twenty six herbs were examined in atrial mechanical dynamics such as pulse pressure and stroke volume and atrial natriuretic peptide (ANP), one of the main hormones involved in the regulation of the body fluid and blood pressure homeostasis in perfused beating rabbit atria. Sophora flavescens Ait., Rheum officinale Baill., Acorus gramineus Sol., Chelidonium majus L., Pulsatilla koreana Nakai., Reynoutria japonica Houtt., Euphorbia lathyris L., Pyrrosia lingua (Thunb.) Farwell, Poncirus trifoliata Rafin., Anemarrhena asphodeloides Bunge, Kochia scoparia Schrad. significantly increased stroke volume and pulse pressure. However, those herbal extracts were not induced ANP secretion. We clarified the eleven herbal extracts for the positive inotropic effect independent of ANP secretion in beating rabbit atria. Thus these results provide a beneficial data for the treatment of the impairment of body fluid and blood pressure in traditional Oriental medicine.
Keywords
Positive inotropic effect; Atrial dynamics; ANP; Stroke volume; Pulse pressure;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Swedberg, K. The future: cardiovascular medicine in 10 years. Heart. 84 Suppl 1: i48-i49, 2000.   DOI
2 Francis, G.S. Pathophysiology of chronic heart failure. Am J Med. 110 Suppl 7A: 37-46, 2001   DOI
3 Lee, H.J., Park, K.S., Kim, K.H., Jung, J.M., Kim, J.K., Park, H.J. The Effect of 12-weeks Regular Exercise on CRP and BNP in Chronic Heart Failure. Korean J Sports Med. 27(1):76-82, 2009.
4 Alpert, N.R., Mulieri L.A., Warshaw D. The failing human heart. Cardiovasc Res 54: 1-10, 2002.   DOI
5 Parissis, J.T., Rafouli-Stergiou, P., Stasinos, V., Psarogiannakopoulos, P., Mebazaa, A. Inotropes in cardiac patients: update 2011. Curr Opin Crit Care. 16(5):432-441, 2010.   DOI
6 Raymer, B., Ebner, D. Small molecule and peptide therapies for chronic heart failure: a patent review (2011 - 2014). Expert Opin Ther Pat. 25(10):1175-1190, 2015.   DOI
7 Opie, L.H. New developments in cardiovascular drugs: heart failure--an informal and personal viewpoint. Cardiovasc Drugs Ther. 11(4):519-520, 1997.   DOI
8 Clerico, A., Iervasi, G., Del Chicca, M.G., Emdin, M., Maffei, S., Nannipieri, M., Sabatino, L., Forini, F., Manfredi, C., Donato, L. Circulating levels of cardiac natriuretic peptides (ANP and BNP) measured by highly sensitive and specific immunoradiometric assays in normal subjects and in patients with different degrees of heart failure. J Endocrinol Invest. 21(3):170-179, 1998.   DOI
9 Yoshimura, M., Yasue, H., Ogawa, H. Pathophysiological significance and clinical application of ANP and BNP in patients with heart failure. Can J Physiol Pharmacol. 79(8):730-735, 2001.   DOI
10 Quan, H.X., Jin, J.Y., Wen, J.F., Cho, K.W. Beta1-adrenergic receptor activation decreases ANP release via cAMP-Ca2+ signaling in perfused beating rabbit atria. Life Sci. 87(7-8):246-253, 2010.   DOI
11 Lee, J.U. Atrial natriuretic peptide attenuates the development of hypertension in 2-kidney, 1-clip goldblatt rats. Kor J Physiol Pharmacol. 23: 43-49, 1989.
12 Tsutamoto, T., Kanamori, T., Wada, A., Kinoshita, M. Uncoupling of atrial natriuretic peptide extraction and cyclic guanosine monophosphate production in the pulmonary circulation in patients with severe heart failure. J Am Coll Cardiol 20: 541-546, 1992.   DOI
13 Macheret, F., Heublein, D., Costello-Boerrigter, L.C., Boerrigter, G., McKie, P., Bellavia, D., et al. Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP. J Am Coll Cardiol. 60(16):1558-1565, 2012.   DOI
14 Kim, H.K., Jo, K.H., Lee, W.C., Kim, Y.S., Bhae, H.S., Lee, K.S., Goo, B.H. The oriental medical study to the causes and symptoms of heart failure. Korean J Orient Int Med. 11(1):61-75, 1990.
15 Ju, Y.S. Ungok Herbology. Woosuk, 2013.
16 Kim, D.H., Bae, E.J., Park, S.U., Yoon, S.W., Ko, C.N., Rheu, K.H. A case report of improvement of glomerular filtration rate and anemia in chronic renal failure through herbal medication. Korean J Orient Int Med. 26(2):498-505, 2005.
17 Cho, K.W., Kim, S.H., Kim, C.H., Seul, K.H. Mechanical basis of ANP secretion in beating atria: atrial pulse pressure and ECF translocation. Am J Physiol 268: 1129-1136, 1995.
18 Cho, K.W., Seul, K.H., Kim, S.H., Seul, K.M., Koh, G.Y. Atrial pressure, distension, and pacing frequency in ANP secretion in isolated perfused rabbit atria. Am J Physiol. 260(1 Pt 2):R39-46, 1991.
19 Kim, S.C., Han, M.Y., Park, H.J., Jung, K.H. ERK mediated suppressive effects of Sophora flavescens on TNF-alpha production in BV2 microglial cells. Kor J Herbology. 22(22):147-153, 2007.
20 Zhou, Y., Xu, W., Han, R., et al. Matrine inhibits pacing induced atrial fibrillation by modulating IKM3 and ICa-L. Int J Biol Sci. 8(1):150-158, 2012.   DOI
21 He, Z.H., He, M.F., Ma, S.C., But, P.P. Anti-angiogenic effects of rhubarb and its anthraquinone derivatives. J Ethnopharmacol. 121(2):313-317, 2009.   DOI
22 Huang, Q., Lu, G., Shen, H.M., Chung, M.C., Ong, C.N. Anti-cancer properties of anthraquinones from rhubarb. Med Res Rev. 27(5):609-630, 2007.   DOI
23 Myung, S.H., Kim, Y.S. Anti-Oxidative and Neuroprotective Effects of Rhei Rhizoma on BV-2 microglia cells and hippocampal neurons. Korean J Orient Physiol Pathol. 19(3):647-655, 2005.
24 Son, Y.J., Kim, Y.S., Lee, Y.J. The Effects of Rheipalmati radix and Rhei undulati Radix on the blood lipids and enzymes of hypercholesterolic rats. Kor J Herbol. 14(1):61-68, 1999.
25 Gilca, M., Gaman, L., Panait, E., Stoian, I., Atanasiu, V. Chelidonium majus-an integrative review: traditional knowledge versus modern findings. Forsch Komplementmed. 17(5):241-248, 2010.   DOI
26 Kim, B.H. Effects of Rhei rhizoma on gastric ulcer in sprague-dawley rats. Korean J Orient Physiol Pathol. 5(1):71-77, 2011.
27 Yokozawa, T., Chen, C.P., Tanaka, T. Direct scavenging of nitric oxide by traditional crude drugs. Phytomedicine. 6(6):453-463, 2000.   DOI
28 Li, X., Kim, H.T., Lee, J.Y., Lee, Y.J., Shin, H.K., Kang, D.G., Lee, H.S. Effect of Acorus gramineus on the relaxation of corpus cavernosum smooth muscle. J Physiol & Pathol Korean Med. 25(5):863-869, 2011.
29 Jang, S.B., Yoo, D.Y. Effects of Chelidonium majus extract on apoptosis induction of MDA-MB-231 human breast cancer cells. J Korean Obstet Gynecol. 28(2):15-25, 2015.   DOI
30 Park, S.J., Song, H.J. Anti-inflammatory effect of extract of Pulsatilla koreana NAKAI in LPS-stimulated murine peritoneal macrophage. Krf. J. Herbology. 22(1):111-117, 2007.
31 Lee, T.K., Kim, J.H., So, J.N. Emodin from Polygonum cuspidatum showed angiogenesis inhibiting activity in vitro. J. Korean Soc. Agric. Chem. Biotechnol. 46(1):50-54, 2003.
32 Yang, W.K., Sung, Y.Y., Kim, H.K. Antithrombotic effect and antiplatelet activity of Polygonum cuspidatum extract. J Korean Soc Food Sci Nutr. 41(2):168-173, 2012.   DOI
33 Kim, D.J., Kim, H.H., Ko, H.. Endothelium Dependent Vasorelaxant effect of aqueous extract of Polygoni cuspidatae Radix on arterial contraction in rabbit. Korean J. Oriental Physiology & Pathology 22(1):131-136, 2008.
34 Kim, S.J., Pakr, S.K. Antioxidative and anti-inflammatory effects of Auranti Fructus. Immaturus pharmacopuncture Korean J acupuncture. 27(2):13-24, 2010.
35 Kim, C.T., Jung, M.H., Kim, H.S., Kim, H.J., Kang, S.J., Kang, S.H. Inhibitors of melanogenesis from Euphorbiae lathyridis Semen. Kor. J. Pharmacognosy. 31: 168-171, 2000.
36 Park, Y.K. Effects of Euphorbiae lathyridis Semen on cell apoptosis in HT-29 human colon cancer cells. Kor. J. Herbology. 22(2):65-72, 2007.
37 Kim, C.M., Shin, M.K., Ahn, D.K., et al. The encyclopedia of oriental herbal medicine. Seoul : Jungdam Pubishing Co. 2004 : 2293.
38 Park, K.C., Bae, G.S., Choi, S.B., Jo, I.J., Gwak, T.S., Lee, G.S., Park, S.J., Song, H.J. Protective effect of Poncirus trifoliata and Citrus aurantium extract on acute pancreatitis in mice model. Korean J acupuncture. 27(5):9-14, 2012.
39 Jeong, K.K., Kang, H., Myung, E.G., Shim,B.S., Kim, S.H., Choi, S.H., Ahn, K.S. Anti-inflammatory Effect of Anemarrhenae Rhizoma on Collagen Induced Arthritis - a Model for Rheumatoid arthritis in DBA/1J mice and cytokine production in Raw 264.7 cells. Korean J. Oriental Physiology & Pathology 22(6):1416-1422, 2008.
40 Doh, E.S. Antifungal activity and identification of antifungal substances of Anemarrhena asphodeloides Extract. J Nature Science, Joongbu Univ. 8(1):59-70, 1999.
41 Lee, S.H., Ryu S.Y., Choi S.U., No Z.S., Kim S.K., Lee C.O., Ahn J.W. Antitumor agent from the Rhizopme of anemarrabena asphodeloides. Kor J pharmacogn. 26(1):47-50, 1995.
42 Shin, M.G. Clinical Traditional Herbalogy. Seoul, Younglimsa. 2002.
43 Cui, H.Z., Choi, H.R., Choi, D.H., Cho, K.W., Kang, D.G., Lee, H.S. Aqueous extract of Zanthoxylum schinifolium elicits contractile and secretory responses via beta1-adrenoceptor activation in beating rabbit atria. J Ethnopharmacol. 126(2):300-307, 2009.   DOI
44 Kubo, M., Matsuda, H., Dai, Y., Ido, Y., Yoshikawa, M. Study on Kochiae Fructus. I. Antipruritogenic effect of 70% ethanol extract from kochiae fructus and its active component. Yakugaku Zasshi. 117(4):193-201, 1997.   DOI
45 Kim, J.S., Han, J.B., Whang, W.W., Min, B.I. Effects of Kochiae fructus on histamine-induced Itch, erythema and wheal responses in normal healthy adults. J Korean Oriental Med. 24(1):133-140, 2003.
46 Kwon, O.J., Oh, H.C., Lee, Y.J., Kim, H.Y., Tan, R., Kang, D.G., Lee, H.S. Sibjotang increases atrial natriuretic peptide secretion in beating rabbit atria. Evid Based Complement Alternat Med. 2015: 268643, 2015.