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http://dx.doi.org/10.15188/kjopp.2015.10.29.5.394

Effects of Hyangsayangyi-tang Aqueous Extracts on the Hypothyroidism Related Hepatic Damages induced by PTU in Rats  

Joo, Jeong-Hyun (Department of Korean Internal Medicine, College of Korean Medicine, Daegu Haany University)
Choi, Hong-Sik (Department of Korean Internal Medicine, College of Korean Medicine, Daegu Haany University)
Kim, Seung-Mo (Department of Korean Internal Medicine, College of Korean Medicine, Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.29, no.5, 2015 , pp. 394-402 More about this Journal
Abstract
To evaluate the benefits of Hyangsayangyi-tang aqueous extracts (HSYYT) on the propylthiouracil (PTU)-induced Rat hypothyroidism. 6 groups, each consisting 8 Rats were used in the present study - Intact vehicle control, PTU control, LT4, HSYYT 500, 250 and 125 ㎎/㎏ treated groups. HSYYT was given, once day for 42 days from 2 weeks before start of PTU treatment as an oral dose of 500, 250 and 125 ㎎/㎏(body weight), and for 28 days while the PTU 10 ㎎/㎏ by daily subcutaneous treatment induced hypothyroidism. Compared the results with LT4 0.5 ㎎/㎏ intraperitoneally treated rats in this experiment. Results of the PTU treatment included; decreases of body weight, increase in thyroid weight, decrease in liver weight, in serum T3, and T4 level decrease with increase of serum TSH levels, in serum HDL increase and in TG content decrease, decrease in liver antioxidants defense system, increase of serum AST levels were observed. However, these PTU induced hypothyroidism and related hepatic damages were dose-dependently inhibited by treatment of HSYYT 500 and 250 ㎎/㎏, and they also effectively regulated the PTU-induced abnormal antioxidant defense system changes in liver. Therefore, in comparison with the PTU control group, it was effective and advantageous changes were not observed in HSYYT 125 ㎎/㎏ treated rats on the PTU induced hypothyroidism and related hepatic damages. In this experiment, HSYYT 500 and 250 ㎎/㎏ dose-dependently inhibited PTU-induced hypothyroidism and related liver damage in rats but not in HSYYT 125 ㎎/㎏.
Keywords
Hyangsayangyi-tang; Hypothyroidism; Hepatic damage;
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