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http://dx.doi.org/10.15188/kjopp.2015.02.29.1.46

Inhibitory Effects of Portulaca Oleracea Ethanol Extract and Glechoma Hederacea Ethanol Extract on the Periodontitis  

Park, Young Mi (Huvet Co. Ltd.)
Lee, Young-Rae (Center for Metabolic Function Regulation(CMFR), Wonkwang University, Department of Oral Biochemistry, and Institute of Biomaterial - Implant, College of Dentistry, Wonkwang University)
Park, Sang Hoon (Huvet Co. Ltd.)
Lee, Bong Gun (Huvet Co. Ltd.)
Park, Yeon Ju (Huvet Co. Ltd.)
Oh, Hong Geun (Huvet Co. Ltd.)
Moon, Dae In (Huvet Co. Ltd.)
Son, Min Woo (Huvet Co. Ltd.)
Kang, Yang Gyu (Heawon, Ltd.)
Kim, Ok Jin (Center for Animal Resources Development, Wonkwang University)
Lee, Seok-Ryun (Department of Conservative Dentistry, College of Dentistry, Wonkwang University)
Lee, Choong Hun (Microelectronics and Display Technology, Next Generation Industrial Radiation Technology RIC, Center for PV Human Resource Development, Wonkwang University)
Kim, Min Seuk (Department of Oral Physiology, and Institute of Biomaterial - Implant, College of Dentistry, Wonkwang University)
Lee, Hak Yong (Huvet Co. Ltd.)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.29, no.1, 2015 , pp. 46-50 More about this Journal
Abstract
Both Portulaca oleracea (PO) and Glechoma hederacea (GH) have been used as traditional medicine due to the multiple pharmacological activities. However, the effects of PO and GH in the pathology of periodontitis is still elusive. In this study, we examined anti-microbial activity of PO ethanol extract (POEE) and GH ethanol extract (GHEE) in vitro, and physiological effects of POEE and GHEE on the cell inflammatory responses and the severity of periodontitis were determined using the rat periodontitis model. Our results indicate that POEE and GHEE had no effects on the proliferation of streptococcus mutans and on LPS-mediated inflammatory responses in gingival fibroblast cells. Notably, ingestion of POEE and GHEE resulted in attenuating the severity of periodontitis and population change of immune cells. These data suggests that PO and GH should be considered as candidates for relieving the severity of periondontitis.
Keywords
Portulaca oleracea; periodontitis; streptococcus mutans;
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