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http://dx.doi.org/10.15188/kjopp.2015.02.29.1.39

Effects of Added Chongmyung-tang on Behavior and Molecular Factors in the Alzheimer's Disease Model  

Kim, Kook Ki (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Choi, Woo Chang (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Kim, Seung Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University)
Namgung, Uk (Department of Neuphysiology, College of Korean Medicine, Daejeon University)
Park, Yang Chun (Division of Respiratory System, Department of Internal Medicine, College of Korean Medicine, Daejeon University)
Kang, Wee Chang (Department of Business Information Statistics, College of Business Adminstration, Daejeon University)
Lee, Sang Ryong (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Jung, In Chul (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.29, no.1, 2015 , pp. 39-45 More about this Journal
Abstract
This experiment was designed to investigate the effect of Added Chongmyung-tang (ACM) on Alzheimer's disease mouse model. Effects of ACM on learning behavior were investigated using the Morris water maze method. Expression levels of molecular factors related to Alzheimer's disease such as glial fibrillary acidic protein (GFAP), cluster of differentiation antigen 68 (CD68), and tau protein in the hippocampus of APP-SWE Tg2576 mice were analyzed by immunofluorescence staining method. ACM reduced escape latency in the Morris water maze test. ACM decreased the expression level of GFAP and tau protein in the hippocampus. These results suggest that ACM may be involved in regulating molecules that are known to play an important role in the pathogenesis of Alzheimer's disease.
Keywords
ACM; Dementia; Alzheimer disease;
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