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http://dx.doi.org/10.15188/kjopp.2015.02.29.1.33

Inhibitory Effects of Black currant seed oil on 2,4-D initrochlorobenzene Induced Atopic Dermatitis in BALB/c Mice Model  

Lee, Ye Seo (Department of Public Health, College of Natural Sciences, Keimyung University)
Park, Kyo Hyun (Department of Public Health, College of Natural Sciences, Keimyung University)
Kim, Bae Hwan (Department of Public Health, College of Natural Sciences, Keimyung University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.29, no.1, 2015 , pp. 33-38 More about this Journal
Abstract
This study investigated the clinical parameters of atopic dermatitis and evaluated the inhibitory effects of Black currant seed oil for atopic dermatitis by using a Dinitrochlorobenzene(DNCB) induced BALB/c mice model. Five-week-old BALB/c mice were divided into four groups: normal group (N, non-treated), control group (C, atopic dermatitis-induced), positive control group (PC, Tacrolimus ointment-treated against induced atopic dermatitis, PC), experiment group (E, Black currant seed oil-treated against induced atopic dermatitis). After induction of atopic dermatitis by DNCB, the erythema, edema, eschar, and scratching were severely observed. The symptoms of atopic dermatitis were improved after 2 weeks, and almost disappeared after 4 weeks in PC and E group. The increased frequencies of scratching in C group were decreased in PC and E group. Transepidermal water loss, erythema index and serum IgE level were significantly decreased in E and PC compared to that in C after 4 weeks of the treatment. The results indicated that Black currant seed oil can relieve atopic dermatitis symptoms effectively, and may be possibly used as a functional material for suppression of atopic dermatitis.
Keywords
Black currant seed oil; atopic dermatitis; BALB/c mice; DNCB;
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