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http://dx.doi.org/10.15188/kjopp.2015.02.29.1.11

Beneficial Effect of Rubus Coreanus Miq in a Rat Model of High Fructose Diet-induced Metabolic Syndrome  

Kho, Min Chul (College of Korean Medicine, Wonkwang University)
Lee, Yun Jung (College of Korean Medicine, Wonkwang University)
Yoon, Jung Joo (College of Korean Medicine, Wonkwang University)
Kang, Dae Gill (College of Korean Medicine, Wonkwang University)
Lee, Ho Sub (College of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.29, no.1, 2015 , pp. 11-17 More about this Journal
Abstract
Overconsumption of fructose results in dyslipidemia, hypertension, which have documented as a risk of cardiovascular diseases. This experimental study was designed to investigate the beneficial effects of Rubus coreanus Miq.(RCM) in high-fructose diet-induced metabolic syndrome. Animals were divided into three groups; Control group fed regular diet and tap water, fructose groups were fed the 65% high-fructose (HF) diet with/without RCM 100 mg/kg/day for 8 weeks, respectively. Chronic treatment with RCM significantly decreased body weight, fat weight and adipocyte size. Moreover, RCM significantly prevented the development of the metabolic disturbances such as hyperlipidemia and hypertension. RCM also led to increase in high density lipoprotein level in the HF group. In addition, RCM suppressed vascular cell adhesion molecule-1 (VCAM-1) expression and significantly recovered the levels of endothelial nitric oxide synthase (eNOS) expression in aorta. These results demonstrates that RCM may be a beneficial therapeutic for metabolic syndrome through the improvement of hyperlipidemia, obesity, and hypertension.
Keywords
Rubus coreanus Miq; metabolic syndrome; obesity; hyperlipidemia; hypertension;
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