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Commelina communis Ledeb Inhibits Melanin Synthesis in Alpha-MSH-stimulated B16F10 Cells  

Kang, Moon Kyung (Department of Food Industry Convergence, College of Human Environmental Science, Wonkwang University)
Lee, Young Eun (Department of Food Industry Convergence, College of Human Environmental Science, Wonkwang University)
Woo, Won Hong (Department of Anatomy, College of Korean Medicine, Wonkwang University)
Mun, Yeun Ja (BK21-plus Team, Professional Graduate School of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.28, no.5, 2014 , pp. 506-511 More about this Journal
Abstract
Commelina communis Ledeb is a widely used medication for the treatment of antidiabetic, antioxidant and hypoglycemic agent in Korea. Alpha-melanocyte stimulating hormone (${\alpha}$-MSH) is a major factor to stimulate melanin synthesis in the skin. The purposes of this study was to investigate the inhibitory effects of extract from Commelina communis Ledeb (ECC) on ${\alpha}$-MSH-stimulated melanogenesis in B16F10 cells. ECC suppressed melanin synthesis and intracellular tyrosinase activity in B16F10 cells or ${\alpha}$-MSH-induced B16F10 cells in a dose dependent manner. In study on the melanogenic protein expressions, it had especially influence on expressions of tyrosinase and tyrosinase-related protein (TRP-1). Tyrosinase and TRP-1 expressions were gradually decreased in a dose-dependent. Additionally, the extract also decreased the ${\alpha}$-MSH-induced over-expression of tyrosinase and TRP-1. This results show that the anti-melanogenic activity of ECC is correlated with the suppression of tyrosinase and TRP-1 protein expressions in B16F10 cells.
Keywords
Commelina communis Ledeb; melanin; tyrosinase; TRP-1; ${\alpha}$-MSH;
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